中国中医药信息杂志2024，Vol.31Issue(5)：172-177,6.DOI:10.19879/j.cnki.1005-5304.202308202
基于代谢组学探讨中医肾虚证物质基础研究概况
Discussion on Research Overview of Material Basis of TCM Kidney Deficiency Syndrome Based on Metabonomics
摘要
Abstract
"Syndrome"is the theoretical cornerstone of TCM syndrome differentiation and treatment,and the phenomic study of syndrome is the key link to answer the scientific questions of TCM.Kidney deficiency syndrome is very common in clinical diseases,but its objectification research still has some difficulties,such as confusing understanding of material basis and incomplete evaluation criteria.Metabolomics conforms to the"holistic concept"of TCM and can provide a new perspective to reveal the essence of syndrome theory.It is considered to be the hub and bridge between systems biology and TCM syndrome.This article reviewed the correlation between the complexity and diversity of kidney deficiency syndrome and the instability of the body's metabolic network.It is believed that amino acid metabolism,microbial metabolism,and energy metabolism disorders are the micro material manifestations of TCM kidney deficiency syndrome.Moreover,the endogenous metabolites of the same syndrome type of different diseases and different phenotypes of the same syndrome have good differential effects and diagnostic value,which can provide reference for further elucidating the characteristics of TCM syndromes,understanding the essence of kidney deficiency syndrome,and objectively evaluating research.关键词
代谢组学/肾虚证/生物标志物/整体观念/物质基础/科学内涵Key words
metabolomics/kidney deficiency syndrome/biomarker/holistic concept/material basis/scientific connotation分类
医药卫生引用本文复制引用
苏海燕,刘俊宏,王柏清,刘晓燕,牛媛媛,胡彦军,苏怡琴..基于代谢组学探讨中医肾虚证物质基础研究概况[J].中国中医药信息杂志,2024,31(5):172-177,6.基金项目
国家自然科学基金(82160883、81660773) （82160883、81660773）
甘肃省科技计划-重点研发计划(22YF7FA100) （22YF7FA100）
