中国当代儿科杂志2024，Vol.26Issue(4)：350-357,8.DOI:10.7499/j.issn.1008-8830.2309107
中国河北省新生儿败血症病原体构成及耐药性的横断面研究
A cross-sectional study on the pathogen composition and antimicrobial resistance in neonates with sepsis in Hebei Province,China
摘要
Abstract
Objective To study the pathogen composition and antimicrobial resistance characteristics in neonates with sepsis in the Hebei area,providing a basis for optimizing the management strategies for neonatal sepsis in the region.Methods The medical data of neonates with sepsis confirmed by blood culture from 23 hospitals in Hebei Province were collected prospectively from November 1,2021 to December 31,2022.The pathogen composition and antimicrobial resistance characteristics were analyzed in early-onset sepsis(EOS),community-acquired late-onset sepsis(CALOS),and hospital-acquired late-onset sepsis(HALOS)cases.Results A total of 289 neonates were included,accounting for 292 infection episodes,with 117(40.1％)EOS,95(32.5％)CALOS,and 80(27.4％)HALOS cases.A total of 294 pathogens were isolated,with 118(40.1％)from the EOS group,where Escherichia coli(39 strains,33.0％)and coagulase-negative staphylococci(13 strains,11.0％)were the most common.In the CALOS group,95 pathogens were isolated(32.3％),with Escherichia coli(35 strains,36.8％)and group B Streptococcus(14 strains,14.7％)being predominant.The HALOS group yielded 81 isolates(27.6％),with Klebsiella pneumoniae(24 strains,29.6％)and Escherichia coli(21 strains,25.9％)as the most frequent.Coagulase-negative staphylococci showed over 80％resistance to penicillin antibiotics.Escherichia coli and Klebsiella pneumoniae showed a resistance rate of 2.2％to 75.0％to common β-lactam antibiotics.The resistance rates of predominant Gram-negative bacteria in the HALOS group to common β-lactam antibiotics were higher than those in the CALOS group.Conclusions In the Hebei region,Escherichia coli is the most common pathogen in both EOS and LOS.There are differences in the composition and antimicrobial resistance of pathogens among different types of neonatal sepsis.The choice of empirical antimicrobial drugs should be based on the latest surveillance data from the region.[Chinese Journal of Contemporary Pediatrics,2024,26(4):350-357]关键词
败血症/病原体/耐药/新生儿Key words
Sepsis/Pathogen/Drug resistance/Neonate引用本文复制引用
河北新生儿败血症研究协作组,马莉..中国河北省新生儿败血症病原体构成及耐药性的横断面研究[J].中国当代儿科杂志,2024,26(4):350-357,8.基金项目
河北省重点研发计划项目(21377709D). （21377709D）
