中国当代儿科杂志2024，Vol.26Issue(4)：378-384,7.DOI:10.7499/j.issn.1008-8830.2310067
缺氧诱导因子1α、Bc1-2/腺病毒E1B19kDa相互作用蛋白3在儿童创伤性脑损伤中的表达及意义
Expression and significance of hypoxia-inducible factor 1a and Bcl-2/adenovirus E1B19kDa-interacting protein 3 in children with traumatic brain injury
摘要
Abstract
Objective To dynamically observe the changes in hypoxia-inducible factor 1α(HIF-1α)and Bcl-2/adenovirus E1B19kDa-interacting protein 3(BNIP3)in children with traumatic brain injury(TBI)and evaluate their clinical value in predicting the severity and prognosis of pediatric TBI.Methods A prospective study included 47 children with moderate to severe TBI from January 2021 to July 2023,categorized into moderate(scores 9-12)and severe(scores 3-8)subgroups based on the Glasgow Coma Scale.A control group consisted of 30 children diagnosed and treated for inguinal hernia during the same period,with no underlying diseases.The levels of HIF-1α,BNIP3,autophagy-related protein Beclin-1,and S100B were compared among groups.The predictive value of HIF-1α,BNIP3,Beclin-1,and S100B for the severity and prognosis of TBI was assessed using receiver operating characteristic(ROC)curves.Results Serum levels of HIF-1α,BNIP3,Beclin-1,and S100B in the TBI group were higher than those in the control group(P＜0.05).Among the TBI patients,the severe subgroup had higher levels of HIF-1α,BNIP3,Beclin-1,and S100B than the moderate subgroup(P＜0.05).Correlation analysis showed that the serum levels of HIF-lα,BNIP3,Beclin-1,and S100B were negatively correlated with the Glasgow Coma Scale scores(P＜0.05).After 7 days of treatment,serum levels of HIF-1α,BNIP3,Beclin-1,and S100B in both non-surgical and surgical TBI patients decreased compared to before treatment(P＜0.05).ROC curve analysis indicated that the areas under the curve for predicting severe TBI based on serum levels of HIF-1α,BN1P3,Beclin-1,and S100B were 0.782,0.835,0.872,and 0.880,respectively(P＜0.05),and for predicting poor prognosis of TBI were 0.749,0.775,0.814,and 0.751,respectively(P＜0.05).Conclusions Serum levels of HIF-1α,BNIP3,and Beclin-1 are significantly elevated in children with TBI,and their measurement can aid in the clinical assessment of the severity and prognosis of pediatric TBI.IChinese Journal of Contemporary Pediatrics,2024,26(4):378-384]关键词
创伤性脑损伤/Bcl-2/腺病毒E1B-19kDa相互作用蛋白3/Beclin-1/缺氧诱导因子1α/儿童Key words
Traumatic brain injury/Bcl-2/adenovirus ElB19kDa-interacting protein 3/Beclin-1/Hypoxia-inducible factor 1α/Child引用本文复制引用
朱磊,王学成,徐妍妍,王楠,朱炳鑫,李政委..缺氧诱导因子1α、Bc1-2/腺病毒E1B19kDa相互作用蛋白3在儿童创伤性脑损伤中的表达及意义[J].中国当代儿科杂志,2024,26(4):378-384,7.基金项目
江苏省卫生健康委科研课题(M2021083) （M2021083）
徐州市科技计划项目(KC21152、KC23148) （KC21152、KC23148）
彭城英才-医学青年后备人才项目(XWRCHT20220021). （XWRCHT20220021）
