组织工程与重建外科杂志2024，Vol.20Issue(2)：220-226,7.DOI:10.3969/j.issn.1673-0364.2024.02.011
全身麻醉与儿童神经认知功能发育异常相关性的研究
Study on the correlation between general anesthesia and abnormal neurodevelopmental outcomes in children
廖过英 1钟林宏 1王帆 2陈天楠 2高毅 2戚传宇 2严佳1
作者信息
- 1. 200011 上海市 上海交通大学医学院附属第九人民医院麻醉科
- 2. 200025 上海市 上海交通大学医学院
- 折叠
摘要
Abstract
Objective To investigate the correlation between general anesthesia and neurodevelopmental outcomes in children.Methods This retrospective cohort study included children under 3 years old who received general anesthesia in our hospital from January 2017 to December 2020 as the anesthesia group,and outpatient or inpatient children aged 3 to 6 years old who did not receive general anesthesia during September 2022 to August 2023 as the control group.From September 2022 to August 2023,the study population was assessed for abnormal neurodevelopmental outcomes by the mental developmental screening test(DST)at 0-6 years of age.The DST evaluated gross motor,fine motor,language,adaptive behavior,and social and self-care.The t-tests were conducted to compare scores on different dimensions between the two groups.Linear regression analyses were performed to assess the associations between general anesthesia and children's neurodevelopmental outcomes after adjusting for con-founders.Stratified analyses were conducted to explore the impact of general anesthesia on neurodevelopmental outcomes in children based on different age ranges of exposure.Results A total of 336 children participated in the study,with 132 in the control group and 204 in the anesthesia group.The testing age was(4.8±1.2)years in both the control and anesthesia groups,and there was no statistically significant difference(P>0.05).Compared with control group,children in the anesthesia group had lower scores in fine motor,adaptive behavior,language,and social and self-care,with statistically significant difference(P<0.05).After adjusting for con-founders,the effects of anesthesia on the adaptive behavior and language remained significant(P<0.05).Stratification analysis according to the age at the time of anesthesia showed that general anesthesia at 0-1 year old was associated with lower scores of adaptive behavior and social and self-care factors(P<0.05),and general anesthesia at 2 to 3 years old was associated with lower language factor scores(P<0.05).Conclusion Exposure to general anesthesia at an early age(<3 years old)is associated with poor neurocognition in adaptive behavior and language.General anesthesia at different ages has different effects on the development of specific nerve functional areas.关键词
全身麻醉/儿童/神经发育/问卷调查Key words
General anesthesia/Children/Neurodevelopment/Questionnaire分类
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廖过英,钟林宏,王帆,陈天楠,高毅,戚传宇,严佳..全身麻醉与儿童神经认知功能发育异常相关性的研究[J].组织工程与重建外科杂志,2024,20(2):220-226,7.
