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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

Morten S.Hansen Kaja Madsen Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch

Bone Research2024，Vol.12Issue(1)：P.180-198,19.

Bone Research2024，Vol.12Issue(1)：P.180-198,19.DOI:10.1038/s41413-023-00312-6

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

Morten S.Hansen ¹Kaja Madsen ²Maria Price ³Kent Søe ⁴Yasunori Omata ⁵Mario M.Zaiss ⁶Caroline M.Gorvin ³Morten Frost ⁷Alexander Rauch⁷

作者信息

1. Molecular Endocrinology Laboratory(KMEB),Department of Endocrinology,Odense University Hospital,DK-5000 Odense C,Denmark Department of Clinical Research,Faculty of Health Sciences,University of Southern Denmark,DK-5000 Odense C,Denmark Clinical Cell Biology,Pathology Research Unit,Department of Clinical Research,University of Southern Denmark,DK-5000 Odense C,Denmark
2. Molecular Endocrinology Laboratory(KMEB),Department of Endocrinology,Odense University Hospital,DK-5000 Odense C,Denmark Department of Clinical Research,Faculty of Health Sciences,University of Southern Denmark,DK-5000 Odense C,Denmark
3. Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes,Endocrinology and Metabolism(CEDAM),University of Birmingham,Birmingham B152TT,UK Centre for Membrane Proteins and Receptors(COMPARE),Universities of Birmingham and Nottingham,Birmingham B152TT,UK
4. Clinical Cell Biology,Pathology Research Unit,Department of Clinical Research,University of Southern Denmark,DK-5000 Odense C,Denmark Department of Molecular Medicine,University of Southern Denmark,DK-5000 Odense C,Denmark
5. Department of Orthopedic Surgery,Faculty of Medicine,The University of Tokyo,Tokyo 113-8655,Japan Department of Internal Medicine 3,Rheumatology and Immunology,Friedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen,D-91054 Erlangen,Germany
6. Department of Internal Medicine 3,Rheumatology and Immunology,Friedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum Erlangen,D-91054 Erlangen,Germany Deutsches Zentrum Immuntherapie(DZI),Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen,D-91054 Erlangen,Germany
7. Molecular Endocrinology Laboratory(KMEB),Department of Endocrinology,Odense University Hospital,DK-5000 Odense C,Denmark Department of Clinical Research,Faculty of Health Sciences,University of Southern Denmark,DK-5000 Odense C,Denmark Steno Diabetes Center Odense,Odense University Hospital,DK-5000 Odense C,Denmark
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摘要

关键词

osteoclast/programming/identif

分类

医药卫生

引用本文复制引用

Morten S.Hansen,Kaja Madsen,Maria Price,Kent Søe,Yasunori Omata,Mario M.Zaiss,Caroline M.Gorvin,Morten Frost,Alexander Rauch..Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity[J].Bone Research,2024,12(1):P.180-198,19.

基金项目

This work was funded by grants from the Novo Nordisk Foundation(NNF18OC0052699)(M.S.H.)and NNF18OC0055047(M.F.) （NNF18OC0052699）

the Region of Southern Denmark(ref:18/17553(M.S.H.)) （ref:18/17553(M.S.H.）

Odense University Hospital(ref:A3147)(M.F.) （ref:A3147）

a faculty fellowship from the University of Southern Denmark(K.M.) （K.M.）

the Lundbeck Foundation(ref:R335-2019-2195)(K.M.and A.R.) （ref:R335-2019-2195）

Academy of Medical Sciences Springboard Award supported by the British Heart Foundation,Diabetes UK （）

the Global Challenges Research Fund （）

the Government Department of Business,Energy and Industrial Strategy and the Wellcome Trust(ref:SBF0041034,C.M.G) （ref:SBF0041034,C.M.G）

a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society(Grant Number 224155/Z/21/Z to C.M.G.). （Grant Number 224155/Z/21/Z to C.M.G.）

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ISSN：2095-4700

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