首页|期刊导航|Bone Research|Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing

Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing

Nan-Yu Zou Ran Liu Mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun Li

Bone Research2024，Vol.12Issue(1)：P.122-136,15.

Bone Research2024，Vol.12Issue(1)：P.122-136,15.DOI:10.1038/s41413-023-00309-1

Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing

Nan-Yu Zou ¹Ran Liu ¹Mei Huang ¹Yu-Rui Jiao ¹Jie Wei ²Yangzi Jiang ³Wen-Zhen He ¹Min Huang ¹Yi-Li Xu ¹Ling Liu ¹Yu-Chen Sun ¹Mi Yang ¹Qi Guo ¹Yan Huang ¹Tian Su ¹Ye Xiao ¹Wei-Shan Wang ⁴Chao Zeng ⁵Guang-Hua Lei ⁶Xiang-Hang Luo ⁷Chang-Jun Li⁷

作者信息

1. Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China
2. Department of Orthopaedics,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China Department of Epidemiology and Health Statistics,Xiangya School of Public Health,Central South University,Changsha,China Hunan Key Laboratory of Joint Degeneration and Injury,Changsha,Hunan 410008,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China
3. School of Biomedical Sciences,Institute for Tissue Engineering and Regenerative Medicine,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China
4. Department of Orthopaedics,The First Affiliated Hospital of Shihezi University,Shihezi,Xinjiang,China
5. Department of Orthopaedics,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China Department of Epidemiology and Health Statistics,Xiangya School of Public Health,Central South University,Changsha,China Hunan Key Laboratory of Joint Degeneration and Injury,Changsha,Hunan 410008,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China
6. Department of Orthopaedics,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China Hunan Key Laboratory of Joint Degeneration and Injury,Changsha,Hunan 410008,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China
7. Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China
折叠

摘要

关键词

healing/union/senescence

分类

医药卫生

引用本文复制引用

Nan-Yu Zou,Ran Liu,Mei Huang,Yu-Rui Jiao,Jie Wei,Yangzi Jiang,Wen-Zhen He,Min Huang,Yi-Li Xu,Ling Liu,Yu-Chen Sun,Mi Yang,Qi Guo,Yan Huang,Tian Su,Ye Xiao,Wei-Shan Wang,Chao Zeng,Guang-Hua Lei,Xiang-Hang Luo,Chang-Jun Li..Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing[J].Bone Research,2024,12(1):P.122-136,15.

基金项目

This work was supported by the National Key R&D Program of China(Project No.2019YFA0111900 to C.J.L.and Y.J.,2022YFC3601900 to G.H.L.,2022YFC3601903 to X.H.L.,and 2022YFC3601905) （Project No.2019YFA0111900 to C.J.L.and Y.J.,2022YFC3601900 to G.H.L.,2022YFC3601903 to X.H.L.,and 2022YFC3601905）

the National Natural Science Foundation of China(Grant Nos.82261160397,82272560,81922017 to C.J.L.and 81930022,91749105 to X.H.L.) （Grant Nos.82261160397,82272560,81922017 to C.J.L.and 81930022,91749105 to X.H.L.）

the NSFC/RGC Joint Research Scheme,the Research Grants Council(UGC)of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China(NSFC/RGC Project No.N_CUHK483/22 to Y.J.) （UGC）

the Hunan Provincial Science and Technology Department(2023JJ30896 to C.J.L.) （2023JJ30896 to C.J.L.）

the Key Research and Development Program of Hunan Province(2022SK2023 to C.J.L.) （2022SK2023 to C.J.L.）

the Science and Technology Innovation Program of Hunan Province(2023RC1027 to C.J.L.,2022RC1009 to J.W,and 2022RC3075 to C.Z.). （2023RC1027 to C.J.L.,2022RC1009 to J.W,and 2022RC3075 to C.Z.）

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