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RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

Luis F.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn Taylor Vivian Szymczuk Brendan Boyce Daniel Martin Vardit Kram Rebeca Galisteo Kamran Melikov Leonid V.Chernomordik Michael T.Collins Alison M.Boyce

Bone Research2024，Vol.12Issue(1)：P.165-179,15.

Bone Research2024，Vol.12Issue(1)：P.165-179,15.DOI:10.1038/s41413-023-00311-7

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

Luis F.de Castro ¹Jarred M.Whitlock ²Zachary Michel ¹Kristen Pan ³Jocelyn Taylor ⁴Vivian Szymczuk ⁴Brendan Boyce ⁵Daniel Martin ⁶Vardit Kram ⁴Rebeca Galisteo ¹Kamran Melikov ²Leonid V.Chernomordik ²Michael T.Collins ¹Alison M.Boyce⁴

作者信息

1. Skeletal Disorders and Mineral Homeostasis Section,National Institute of Dental and Craniofacial Research,National Institutes of Health,Bethesda,MD,USA
2. Section on Membrane Biology,Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA
3. Metabolic Bone Disorders Unit,National Institute of Dental and Craniofacial Research,National Institutes of Health,Bethesda,MD,USA Department of Plastic and Reconstructive Surgery,The Johns Hopkins Medical Institutions,Baltimore,MD,USA
4. Metabolic Bone Disorders Unit,National Institute of Dental and Craniofacial Research,National Institutes of Health,Bethesda,MD,USA
5. Department of Pathology and Laboratory Medicine,University of Rochester Medical Center,Rochester,NY,USA
6. NIDCR Genomics and Computational Biology Core,National Institute of Dental and Craniofacial Research,National Institutes of Health,Bethesda,MD,USA
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摘要

关键词

dysplasia/treatment/finding

分类

医药卫生

引用本文复制引用

Luis F.de Castro,Jarred M.Whitlock,Zachary Michel,Kristen Pan,Jocelyn Taylor,Vivian Szymczuk,Brendan Boyce,Daniel Martin,Vardit Kram,Rebeca Galisteo,Kamran Melikov,Leonid V.Chernomordik,Michael T.Collins,Alison M.Boyce..RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia[J].Bone Research,2024,12(1):P.165-179,15.

基金项目

This work was supported by the Intramural Research Program of the NIDCR,NICHD （）

Clinical Center,National Institutes of Health.The clinical trial NCT03571191 was conducted as an investigator-sponsored study supported by Amgen,Inc （）

This research was supported in part by the NIDCR Genomics and Computational Biology Core:ZIC DC000086 （）

Veterinary Resources Core:ZIC DE000740-05.Work in the MTC and LVC laboratories was supported by the Research on Women’s Health(ORWH)through the Bench to Bedside Program award#884515. （ORWH）

Bone Research

OAMEDLINE

ISSN：2095-4700

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