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Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis

Yuhang Liu Ruihan Hao Jia Lv Jie Yuan Xuelei Wang Churong Xu Ding Ma Zhouyi Duan Bingjun Zhang Liming Dai Yiyun Cheng Wei Lu Xiaoling Zhang

Bone Research2024，Vol.12Issue(1)：P.215-226,12.

Bone Research2024，Vol.12Issue(1)：P.215-226,12.DOI:10.1038/s41413-024-00318-8

Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis

Yuhang Liu ¹Ruihan Hao ¹Jia Lv ²Jie Yuan ³Xuelei Wang ⁴Churong Xu ⁵Ding Ma ¹Zhouyi Duan ¹Bingjun Zhang ¹Liming Dai ¹Yiyun Cheng ²Wei Lu ⁴Xiaoling Zhang¹

作者信息

1. Department of Orthopedic Surgery,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM),Shanghai 200092,China National Facility for Translational Medicine,Shanghai 200240,China
2. Shanghai Frontiers Science Center of Genome Editing and Cell Therapy,Shanghai Key Laboratory of Regulatory Biology,School of Life Sciences,East China Normal University,Shanghai 200241,China
3. Department of Orthopaedic Surgery,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China
4. CAS Key Laboratory of Tissue Microenvironment and Tumor,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China
5. School of Medicine,Shanghai University,Shanghai 200444,China
折叠

摘要

关键词

osteoarthritis/metabolism/inhibited

分类

医药卫生

引用本文复制引用

Yuhang Liu,Ruihan Hao,Jia Lv,Jie Yuan,Xuelei Wang,Churong Xu,Ding Ma,Zhouyi Duan,Bingjun Zhang,Liming Dai,Yiyun Cheng,Wei Lu,Xiaoling Zhang..Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis[J].Bone Research,2024,12(1):P.215-226,12.

基金项目

This work was supported by grants from National Natural Science Foundation of China(81830078,82071868,32370892) （81830078,82071868,32370892）

Science and Technology Commission of Shanghai Municipality(23141901200) （23141901200）

Health Commission of Shanghai Municipality(2022JC029) （2022JC029）

Biomaterials and Regenerative Medicine Institute Cooperative Research Project,Shanghai Jiaotong University School of Medicine(2022LHA11) （2022LHA11）

Shanghai Key Laboratory of Orthopedic Implant(No.KFKT202206). （No.KFKT202206）

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