Genetically modified pigs:Emerging animal models for hereditary hearing lossOACSTPCD
Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for society.To investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are necessary.Pigs have been extensively used as valuable large animal models in biomedical research.In this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing loss.Additionally,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL research.Overall,this review provides insights and perspectives for future studies on HHL using porcine models.
Xiao Wang;Tian-Xia Liu;Ying Zhang;Liang-Wei Xu;Shuo-Long Yuan;A-Long Cui;Wei-Wei Guo;Yan-Fang Wang;Shi-Ming Yang;Jian-Guo Zhao
State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China State Key Laboratory of Animal Biotech Breeding,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing,100193,ChinaState Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,ChinaState Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,ChinaDepartment of Otolaryngology-Head and Neck Surgery,Institute of Otolaryngology,Chinese PLA General Hospital,Beijing 100853,ChinaDepartment of Otolaryngology-Head and Neck Surgery,Institute of Otolaryngology,Chinese PLA General Hospital,Beijing 100853,ChinaState Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui 230022,ChinaDepartment of Otolaryngology-Head and Neck Surgery,Institute of Otolaryngology,Chinese PLA General Hospital,Beijing 100853,ChinaState Key Laboratory of Animal Biotech Breeding,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing,100193,ChinaDepartment of Otolaryngology-Head and Neck Surgery,Institute of Otolaryngology,Chinese PLA General Hospital,Beijing 100853,ChinaState Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,China Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China
临床医学
PigsAnimal modelsHereditary hearing lossGenetic modificationInner ear
《Zoological Research》 2024 (2)
P.284-291,8
supported by the National Key Research and Development Program of China (2021YFA0805902,2022YFF0710703)National Natural Science Foundation of China (32201257)Science and Technology Innovation Project of Xiongan New Area (2022XAGG0121)Young Elite Scientists Sponsorship Program by the China Association for Science and Technology (2019QNRC001)。
评论