北华大学学报（自然科学版）2024，Vol.25Issue(3)：314-318,5.DOI:10.11713/j.issn.1009-4822.2024.03.006
五味子酯乙对高脂血症小鼠血脂水平的影响
Effects of Schisantherin B on Blood Lipid Levels in Hyperlipidaemic Mice
摘要
Abstract
Objective To investigate the effect of Schisantherin B,the active ingredient of Schisandra chinensis lignans,on lipid metabolism in hyperlipidaemic mice.Method 90 male C57BL/6 mice were randomly divided into six groups of 15 mice each,control group,model group,Schisandra chinensis total lignans group (50 mg/kg) ,Schisantherin B low (2 mg/kg) ,medium (4 mg/kg) ,and high (8 mg/kg) dose groups.All groups except control group were kept on high fat diet (HFD) for 12 weeks and the drug was administered by gavage in the 8th week to each group,the control and model groups were given the same volume of solubiliser for 4 weeks.The blood and liver were taken at the end of the administration,and body weight,liver index,serum levels of TG,TC,LDL-C and HDL-C were measured.HE staining was used to observe the pathomorphological changes in the liver.Results Compared with the control group,the body weight of model group increased significantly,liver index increased (P<0.01),serum levels of TG,TC and LDL-C increased (P<0.01),and the level of HTD-C decreased (P<0.01).There were a large number of fat vacuoles of different sizes in the cytoplasm of liver cells,and the arrangement of liver cords was disordered.Compared with model group,the body weight of mice in each administration group increased gently after administration,liver index,levels of TG,TC and LDL-C decreased (P<0.05 or P<0.01),level of HDL-C increased (P<0.05 or P<0.01),and HE staining of liver tissue showed improved steatosis.Conclusion Schisantherin B can disrupt blood lipids and improve liver steatosis in hyperlipidemic mice.关键词
五味子木脂素/五味子酯乙/高脂血症Key words
Schisandra chinensis lignans/Schisantherin B/hyperlipidaemic分类
医药卫生引用本文复制引用
王阔,曾钦成,万久琛,宋兆芮,张志宏,王春梅,李贺,陈建光,孙靖辉..五味子酯乙对高脂血症小鼠血脂水平的影响[J].北华大学学报（自然科学版）,2024,25(3):314-318,5.基金项目
国家自然科学基金面上项目(82274081). （82274081）
