Journal of Changshu Institute of Technology2024，Vol.38Issue(2)：51-56,6.
响应面法优化姜黄素凝胶剂及其稳定性评价
Optimization of Curcumin Gel Formulation by Response Surface Methodology and Estimation of its Stability
摘要
Abstract
Gel is a kind of semi-solid preparation commonly used in dermatology. It has the characteristics of easy absorption of tissue fluid, strong adjustability, good stability and high safety. In this study, appearance, coating malleability, cold and heat resistance, and centrifugal stability were used as sensory indexes. The preparation process of curcumin gel was optimized by single-factor experiment and response surface optimization experiment, and the bacteriostatic performance of curcumin was preliminarily tested by Oxford cup method. The results show that under the said experimental conditions, the optimal formula of the gel matrix was 0.5％ carbomer 940, 0.5％ glycerin, 1.0％ triethanolamine, and curcumin 0.5～2.0 mg/g. The gel is bright yellow and has good coating ductility. Its stability indexes such as cold resistance, heat resistance and centrifugation all meet the quality requirements of the 2020 edition of Chinese Pharmacopoeia for gels.关键词
姜黄素/凝胶剂/响应面法/牛津杯法/稳定性Key words
curcumin/gels/response surface method/Oxford cup method/stability分类
医药卫生引用本文复制引用
刘欣语,王玉婷,邰广鑫,潘红英,张晶..响应面法优化姜黄素凝胶剂及其稳定性评价[J].Journal of Changshu Institute of Technology,2024,38(2):51-56,6.基金项目
常熟理工学院校级大学生创新创业训练计划项目"姜黄素凝胶剂的配方优化及其体外释放度的研究"(XJDC2023195) （XJDC2023195）
