在线固相萃取/超高效液相色谱-串联质谱测定地表水中90种药品及个人护理用品OA北大核心CSTPCD

This study established an online solid phase extraction(OSPE)/ultrahigh performance liq-uid chromatography tandem mass spectrometry(UPLC-MS/MS)method for the determination of 90 pharmaceutical and personal care products(PPCPs)in surface water.After filtration,the water sam-ple was directly injected into the OSPE column for purification and enrichment,and the target sub-stances were transferred to the analysis column for further separation and analysis through valve switching.Using a Waters HSS T3 C18(100 mm×2.1 mm,1.8 µm)chromatographic column for sep-aration,with 0.1%formic acid aqueous solution and acetonitrile as the mobile phase for elution.The analytes were detected in multiple reaction monitoring(MRM)mode through positive and negative electrospray ionization(ESI),and quantified with internal standard method.Under optimized chro-matography-mass spectrometry conditions,90 PPCPs showed good linear relationships with the cor-relation coefficients(r2)more than 0.99.The detection limits reached 0.06-10.00 ng/L,and the quantitation limits reached 0.24-40.00 ng/L.The recoveries in actual samples analyzed at spiked concentrations of 10,20,and 100 ng/L were between 81.2%and 120%,with relative standard devi-ations(n=7)of most compounds less than 10%.This method has high analysis efficiency,sensitivity,and stable operation,and could be used as a monitoring method for analyzing PPCPs in surface water samples.