基于硅胶腕带被动采样/气相色谱-质谱法的大学生群体合成麝香暴露监测研究OA北大核心CSTPCD

Synthetic musks(SMs)are widely utilized as flavor additives in everyday washing,and prolonged exposure to SMs may present potential health risks to humans.This study employs silicone bracelet as passive sampler for the collection of daily exposure to SMs among college students.After extraction with ethyl acetate solution,the samples were concentrated with solid phase extraction(SPE).The concentration of SMs in individual samples was detected by gas chromatography-mass spectrometry(GC-MS)and internal standard method,while the health risks associated with SMs ex-posure were assessed by hazard quotient(HQ).The findings demonstrate that the galaxolide(HHCB)and tonalide(AHTN)were linear in the range of 5-500 µg/L,with linear correlation coefficients(r2)more than 0.999.The limits of detection for the analytes were 1.2-6.6 µg/L and the limits of quanti-tation were 4.10-21.9 µg/L.The recoveries of HHCB and AHTN ranged from 91.6%to 113%and from 92.7%to 118%,with relative standard deviations(RSDs)ranging from 1.9%to 15%and from 0.81%to 11%,respectively.The average daily exposure to HHCB and AHTN was found to be 2.60 µg/(kg·d)and 0.23 µg/(kg·d),respectively,among the college student population.The HQ of SMs dermal exposure is below 1,indicating no significant human health risk to the college student population.The study results confirm the silicone bracelet's potential as a new passive sampling de-vice for researching human compound exposure,offering valuable data and research methods for in-vestigating chemical exposure and assessing human health risks.