基于双金属材料的电化学适体传感器用于磺胺二甲氧嘧啶检测OA北大核心CSTPCD

The development of detection techniques for the accurate determination of sulfadimethox-ine(SDM)is crucial in food safety.In this study,nickel-zinc bimetallic microflowers(Ni-Zn MFs)with excellent electrochemical activity were utilized as an electrochemical sensing platform,while re-duced graphene oxide(rGO)modified with Aurum-Manganese nanoparticles(AuMn NPs)was intro-duced as an electrical signal hindering molecule(AuMn/rGO,AMG).On this basis,a highly sensi-tive biosensor for the determination of SDM was developed.When SDM is present,it can specifically bind to the binding Aptamer(Apt)-labeled AMG(AMG-Apt),which carries the electrical signal hin-dering molecules away from the electrode surface and amplifies the electrochemical signal of the redox probe[Fe(CN)6]3-/4-.The proposed aptasensor for the detection of SDM showed good linearity in the range of 1 pg/mL-100 ng/mL with a low limit of detection(LOD)of 0.26 pg/mL.Notably,this bio-sensor also showed satisfactory results in milk samples,which is expected to be applied in food safety analysis.