分析测试学报2024，Vol.43Issue(5)：798-804,7.DOI:10.12452/j.fxcsxb.23121148
质谱技术在脑卒中生物标志物发现中的应用
Applications of Mass Spectrometry in Stroke Biomarker Discovery
摘要
Abstract
Stroke is a class of diseases caused by a sudden decrease or interruption in cerebral blood supply,resulting in brain tissue damage.It is characterized by high prevalence,high mortality,and high disability rates.Recently,mass spectrometry has demonstrated immense potential in the discovery of disease biomarkers,owing to its high sensitivity and specificity.Notably,from the peri-od before the clinical determination of stroke to recovery,significant changes in metabolites and pro-teins occur in the body of the patient,which may provide opportunities for mass spectrometry-based diagnosis before clinical determination,pre-hospital emergency care,and prognosis assessment.This article primarily reviews the representative works in the discovery of metabolic and protein bio-markers using mass spectrometry over the past decade.In the realm of metabolic biomarkers,we compile those associated with energy metabolites,amino acids,and lipids relevant to stroke.Re-garding protein biomarkers,we discuss stroke-related matrix metalloproteinases,metalloproteins,and fibrinogen,among others.This review is significant in revealing the pathophysiological mecha-nisms of stroke and advancing the application of mass spectrometry for stroke diagnosis in clinical set-ting.关键词
脑卒中/质谱/生物标志物/代谢组学/蛋白组学Key words
stroke/mass spectrometry/biomarkers/metabolomics/proteomics分类
化学化工引用本文复制引用
周旭,赵洪慰,孙昕昊,谢锋,李博岩,张进..质谱技术在脑卒中生物标志物发现中的应用[J].分析测试学报,2024,43(5):798-804,7.基金项目
国家自然科学基金项目(82360700,22004022) （82360700,22004022）
贵州省科技厅科技计划项目(黔科合基础-ZK[2021]一般045) （黔科合基础-ZK[2021]一般045）
贵州省教育厅普通高等学校青年科技人才成长项目(黔教合KY字[2021]163) （黔教合KY字[2021]163）
