摘要
Abstract
Objective To investigate the relationship between the level of lipid protein a[Lp(a)]and the degree of coronary artery disease in patients with coronary heart disease(CHD)and type 2 diabetes mellitus(T2DM).Method A total of 123 patients diagnosed with T2DM were selected,110 of whom were confirmed by coronary angiography(CAG)with CHD,and divided into moderate stenosis group(30 cases)and severe stenosis group(80 cases)according to the degree of coronary artery stenosis.According to the range of coronary artery lesions,the patients were divided into single-vessel lesion group(25 cases),double-vessel lesion group(55 cases)and multi-vessel lesion group(30 cases).In addition,30 volunteers with normal coronary artery artery treated in our hospital during the same period were selected as the control group,and the levels of blood lipid,apolipoprotein A1(ApoA1),Apolipoprotein B(ApoB)and Lp(a)in each group were measured.Results Compared with the con-trol group,TG and Lp(a)levels were higher in the CHD with T2DM group,but HDL-C level was lower than that in the control group(P＜0.05).The Lp(a)levels in control group,moderate stenosis group and severe stenosis group were(115.20±54.09)mg/L,(158.90±65.12)mg/L and(183.20±55.45)mg/L,with severe stenosis group＞moderate stenosis group＞control group.Lp(a)levels in control group,single arm group,double arm group and multi-arm lesion group were(115.20±54.09)mg/L,(128.90±68.23)mg/L,(186.47±91.23)mg/L,(261.90±109.47)mg/L.Multibranch lesion group＞double-branch lesion group＞single-branch lesion group(P＜0.05),but there was no significant difference in Lp(a)level between single-branch lesion group and control group(P＞0.05).When Lp(a)＞147.82mg/L,the AUC of CHD with T2DM was 0.821(0.747-0.881),and the sensitivity and specifi city were 77.27%and 83.33%,respectively(P＜0.05).Conclusion The level of Lp(a)in CHD patients with T2DM increases with the severity of coronary artery stenosis and the increase of coronary artery number.Lp(a)can be used as an important aux-iliary index to determine the severity of coronary artery lesions to assist clinical diagnosis and treatment.关键词
冠心病/2 型糖尿病/血脂蛋白a/冠状动脉疾病/血脂代谢Key words
coronary heart disease/Type 2 diabetes mellitus/Lipoprotein a/Coronary artery disease/Lipid metabolism分类
医药卫生
