哈尔滨医药2024，Vol.44Issue(2)：31-33,3.DOI:10.3969/j.issn.1001-8131.2024.02.010
二维斑点追踪技术评价曲妥珠单抗联合蒽环类药物对乳腺癌患者心脏毒性的价值
Evaluation of Trastuzumab Combined with Anthracycline Drugs Using Two-dimensional Dot Tracking Technology The value of Cardiotoxicity in Patients with Breast Cance
摘要
Abstract
Objective To explore the value of two-dimensional dot tracking technique in early monitoring left ventricu-lar systolic function in evaluating the cardiac toxicity of patients with breast cancer after treatment with trastuzumab com-bined with anthracycline drugs.Methods 50 cases of postoperative breast cance,All patients were treated with trastuzumab combined with anthracycline drugs.Routine monitoring of electrocardiogram,two-dimensional echocardiography,and two-dimen-sional spot tracking technology before,during,and after treatment.The main outcome measures were left ventricular ejection fraction(LVEF)and overall longitudinal strain(GLS).30 healthy volunteers served as the control group.Results(1)GLS sig-nificantly decreased in the middle and late stages of chemotherapy compared to the control group and before chemotherapy(P＜0.05);(2L)There was no significant difference in LVEF between the pre chemotherapy group and the control group in the middle and late stages of chemotherapy.Conclusions The global longitudinal strain value(GLS)measured by two-dimen sional spot tracking technology can evaluate the small changes of drug induced left ventricular dysfunction in breast cancer patients after treatment,and detect the damage of myocardial function as soon as possible.关键词
二维斑点追踪技术/乳腺癌/蒽环类药物/曲妥珠单抗/心脏毒性Key words
2D speckle tracking technology/breast cancer/Anthracycline drugs/trastuzumab/cardiotoxicity分类
医药卫生引用本文复制引用
董燕,谢艳林,甘曼..二维斑点追踪技术评价曲妥珠单抗联合蒽环类药物对乳腺癌患者心脏毒性的价值[J].哈尔滨医药,2024,44(2):31-33,3.基金项目
广州市卫生健康科技项目(20211A011002) （20211A011002）
