哈尔滨医药2024，Vol.44Issue(2)：37-40,4.DOI:10.3969/j.issn.1001-8131.2024.02.012
DCE-MRI定量参数联合血清VEGF、ProGRP水平检测对肺部良恶性病变的鉴别诊断价值
Value of DCE-MRI Quantitative Parameters Combined with Serum VEGF and ProGRP Levels in Differential Diagnosis of Benign and Malignant Lung Lesions
摘要
Abstract
Objective To evaluate the value of quantitative parameters of dynamic enhanced magnetic resonance imag-ing(DCE-MRI)combined with serum vascular endothelial growth factor(VEGF)and ProGRP levels in the differential diagnosis of benign and malignant lung lesions.Methods 95 patients with suspected lung cancer were retrospectively selected and di-vided into benign lesions(46 cases)and malignant lesions(49 cases)according to the biopsy results,and were included in the benign group and malignant group,respectively.The imaging findings of the two groups were compared.Quantitative parameters of DCE-MRI[rate constant(Kep),volume transfer constant(Ktrans),extracellular space volume ratio(Ve)]and serum levels of VEGF and ProGRP were compared between the two groups.To analyze the diagnostic value of DCE-MRI quantitative param-eters combined with serum VEGF and ProGRP levels in malignant lung lesions.Results The proportion of irregular shape,edge burr sign,uneven internal enhancement and early enhancement rate≥60%in the malignant group was higher than that in the benign group(P＜0.05).The levels of Kep,Ktrans,Ve and serum VEGF and ProGRP in the malignant group were high-er than those in the benign group.The AUC for the combined diagnosis of malignant lung lesions was 0.898,the optimal di-agnostic sensitivity was 91.84%,the specificity was 86.96%,and the Yoden index was 0.788.Conclusion Quantitative pa-rameters Kep,Ktrans,Ve and serum VEGF and ProGRP levels of DCE-MRI are closely related to malignant lung lesions.The combined detection has certain diagnostic value,and can be used as an effective method for differentiating benign and malig-nant lung lesions.关键词
动态增强磁共振成像/血管内皮生长因子/胃泌素释放肽前体/肺部病变/鉴别诊断Key words
Dynamic enhanced magnetic resonance imaging/Vascular endothelial growth factor/Gastrin-releasing peptide precursor/Pulmonary disease/Differential diagnosis分类
医药卫生引用本文复制引用
韩树亮,杨洁,郭孟珂,徐珂..DCE-MRI定量参数联合血清VEGF、ProGRP水平检测对肺部良恶性病变的鉴别诊断价值[J].哈尔滨医药,2024,44(2):37-40,4.基金项目
河南省医学科技攻关计划项目(LHGJ20220654) （LHGJ20220654）
