哈尔滨医药2024，Vol.44Issue(2)：87-89,3.DOI:10.3969/j.issn.1001-8131.2024.02.030
胶囊壳变更对头孢氨苄胶囊溶出曲线的影响研究
Effect of Capsule Shell Change on the Dissolution Curve of Cefalexin Capsules
王威1
作者信息
- 1. 哈药集团制药总厂,黑龙江 哈尔滨 150086
- 折叠
摘要
Abstract
Objective To the effect of capsule shell change on the similarity of dissolution curves of cefalexin capsules.Methods According to the second method(plasma method)of Chinese pharmacopoeia(2020 edition),the solubility of ce-faxime capsules and reference preparations in different pH dissolution media was determined,the similarity of dissolution curves between cefalexin capsules and reference preparations was compared by the method of similarity factor in the non-model dependent method.Results The dissolution curves of cefalexin capsules were compared with those of the reference preparation,and the dissolution curves of two batches of cefalexin capsules were similar to those of the reference prepara-tion,the dissolution curve of another batch of cefalexin capsules in Ph6.8 phosphate medium was not similar to that of the reference preparation.Conclusion The effect of the change of the capsule shell on the similarity of the dissolution curve of cefalexin capsules was studied.关键词
头孢氨苄胶囊/桨法/溶出曲线/相似因子Key words
Cefalexin capsules/OAR method/Dissolution curve/Similarity factor分类
医药卫生引用本文复制引用
王威..胶囊壳变更对头孢氨苄胶囊溶出曲线的影响研究[J].哈尔滨医药,2024,44(2):87-89,3.
