复方五凤草液负压滴灌治疗Ⅲ-Ⅳ期压力性损伤的疗效及其作用机制OA北大核心CSTPCD
Efficacy and mechanism of compound Wufengcao liquid combined with negative pressure wound therapy with instillation in treatment of stage Ⅲ-Ⅳ pressure injury
目的 观察复方五凤草液负压滴灌治疗(NPWTi)Ⅲ-Ⅳ期压力性损伤(PI)的临床疗效,并初步探索其作用机制.方法 (1)临床研究:选取2019年1月-2022年10月于南京市中西医结合医院瘰疬科病区及伤口护理门诊就诊的60例PI患者,随机分为生理盐水NPWTi组与复方五凤草液NPWTi组,每组30例.两组均在全身基础治疗的前提下进行NPWTi,分别于治疗前及治疗第1、2、3周拆除负压装置后统计PI愈合计分量表(PUSH)评分、创面细菌培养检出率及…查看全部>>
Objective To observe the clinical efficacy of compound Wufengcao liquid combined with negative pressure wound therapy with instillation(NPWTi)for the treatment of stage Ⅲ-Ⅳ pressure injury(PI),and to preliminarily explore its action mechanism.Methods(1)Clinical research:from January 2019 to October 2022,60 PI patients who were admitted to the Scrofula Department and Wound Care Clinic at Nanjing Municipal Hospital of Traditional Chinese and Western Medicine w…查看全部>>
曹丽敏;黄子慧;王裕玲;钱佳燕;高贝贝;陈思琪;翁嘉晨
南京中医药大学附属南京市中西医结合医院瘰疬科,江苏南京 210014南京中医药大学附属南京市中西医结合医院瘰疬科,江苏南京 210014南京中医药大学附属南京市中西医结合医院瘰疬科,江苏南京 210014南京中医药大学附属南京市中西医结合医院瘰疬科,江苏南京 210014南京中医药大学附属南京市中西医结合医院瘰疬科,江苏南京 210014南京中医药大学附属南京市中西医结合医院瘰疬科,江苏南京 210014南京中医药大学附属南京市中西医结合医院瘰疬科,江苏南京 210014
临床医学
压力性损伤负压滴灌治疗复方五凤草液巨噬细胞极化p38MAPK/NF-κB信号通路
pressure injurynegative pressure wound therapy with instillationcompound Wufengcao liquidmacrophage polarizationp38 MAPK/NF-κB signaling pathway
《解放军医学杂志》 2024 (4)
396-407,12
This work was supported by the Key Project of Jiangsu Provincial Administration of Traditional Chinese Medicine(ZD202105),the Key Projects of Nanjing Municipal Health Commission(ZKX20049),and the Xu Zhiyin National Famous Traditional Chinese Medicine 江苏省中医药管理局重点项目(ZD202105)南京市卫健委重点项目(ZKX20049)许芝银全国名中医专家工作室([宁卫财务2019]26号)Expert Studio([Ningwei Finance 2019]No.26)
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