解放军医学杂志2024，Vol.49Issue(4)：468-474,7.DOI:10.11855/j.issn.0577-7402.2366.2023.0919
组蛋白去乙酰化酶及其抑制剂在牙源性干细胞成骨和成牙本质分化中的研究进展
Research progress of histone deacetylase and its inhibitors in osteogenesis and odontogenic differentiation of odontogenic stem cells
摘要
Abstract
Histone deacetylases(HDACs)can deacetylate histones,leading to tighter DNA binding,and thereby playing a role in inhibiting gene transcription.On the contrary,histone deacetylase inhibitors(HDACis)can promote chromatin relaxation,enabling various transcription factors to bind specifically to DNA and activate transcription genes.Dental stem cells(DSCs)are human adult stem cells.These cells have the characteristics of less damage and low immune rejection during sampling,and are especially important seed cells in the process of osteogenesis,odontogenesis and other differentiation.A large number of experimental studies have shown that HDACs and HDACis together play important roles in cell division and differentiation,signal transduction,regulation of cellular inflammation and other life processes.This review summarizes the research progress of HDACs and HDACis in regulating osteogenic and odontogenic differentiation of DSCs,aiming to provide insights into the study of the interaction between HDACs and HDACis,and potentially guide clinical application of DSCs in the treatment of tooth and bone injury.关键词
组蛋白去乙酰化酶/组蛋白去乙酰化酶抑制剂/牙源性干细胞/分化Key words
histone deacetylase/histone deacetylase inhibitors/odontogenic stem cells/differentiation分类
医药卫生引用本文复制引用
李东雨,朱小苗,赵继荣,何文喜..组蛋白去乙酰化酶及其抑制剂在牙源性干细胞成骨和成牙本质分化中的研究进展[J].解放军医学杂志,2024,49(4):468-474,7.基金项目
This work was supported by the National Natural Science Foundation of China(81970932),and the Shaanxi Natural Science Basic Research Program-Key Project(2022JZ-42) 国家自然科学基金面上项目(81970932) （81970932）
陕西自然科学基础研究计划-重点项目(2022JZ-42) （2022JZ-42）
