日用化学工业（中英文）2024，Vol.54Issue(5)：520-526,7.DOI:10.3969/j.issn.2097-2806.2024.05.004
4-丁基间苯二酚微乳凝胶制备及美白抗氧化研究
Preparation of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel and its whitening and antioxidative effects
摘要
Abstract
The 4-butylresorcinol-containing cinnamon oil microemulsion-gel was prepared and its pharmaceutical properties were investigated.Its whitening and antioxidant properties were evaluated.Cinnamon oil microemulsion containing 4-butylresorcinol is clear and transparent in appearance.Its particle size is 15.68 nm and the coefficient of dispersity(PDI)is 0.185.The microemulsion-gel is prepared by using carbopol and Bletilla striata(T.)Reichb.F.polysaccharides as the gel matrix with the pH value at 6.0 and the viscosity at 74.8 Pa·s.In this study,the whitening effect of 4-butylresorcinol-containing cinnamon oil microemulsion-gel was determined by measuring the tyrosinase inhibition.It is shown that the tyrosinase inhibition of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel gradually enhances with its concentration increasing.The tyrosinase inhibition activity of microemulsion-gels is higher than that of the free 4-butylresorcinol and arbutin at the same concentration.The antioxidant effect of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel on hydrogen peroxide(H2O2)-induced oxidative damage was tested in B16-F10 cells.The results show that microemulsion-gel has excellent antioxidant effect by reducing ROS production.关键词
4-丁基间苯二酚/肉桂油/微乳凝胶/美白/抗氧化Key words
4-butylresorcinol/cinnamon oil/microemulsion-gel/whitening/antioxidation分类
化学化工引用本文复制引用
魏楚原,张晓萍,潘敬,彭佩,张雅鹃,穆朝峰..4-丁基间苯二酚微乳凝胶制备及美白抗氧化研究[J].日用化学工业（中英文）,2024,54(5):520-526,7.基金项目
国家级大学生创新创业训练计划项目(202210344058X) （202210344058X）
