日用化学工业（中英文）2024，Vol.54Issue(5)：542-549,8.DOI:10.3969/j.issn.2097-2806.2024.05.007
喹诺酮和四环素两类抗生素对蛋白核小球藻的生理生化响应
Physiological and biochemical responses of quinolone and tetracycline antibiotics to Chlorella pyrenoidosa
摘要
Abstract
Quinolones and tetracyclines are prevalent antibiotics in aquatic environment,posing potential ecological risks to the aquatic environment.However,the biochemical harm of these antibiotics to Chlorella pyrenoidosa has not been studied,and studies on the mechanism of their toxic effects in green algae are relatively few.In this work,three common quinolone antibiotics(ofloxacin(OFX),enrofloxacin(ENR)and ciprofloxacin(CIP))and two tetracycline antibiotics(tetracycline(TC)and oxytetracycline(OTC))were used as target contaminants.Their inhibition rates on algal cell growth and their physiological and biochemical responses to chlorophyll,superoxide dismutase(SOD),catalase(CAT),total protein(TP)and trace malondialdehyde(MDA)at 96 h exposure were studied.The results showed that,the effects of growth inhibition for these five antibiotics were all positively correlated with Chl a;the MDA content was increased with increasing concentrations under antibiotic exposure except for CIP;the exposure to two tetracyclines enhanced SOD activity,while the exposure to quinolone antibiotics reduced SOD activity.CIP promoted the growth of Chlorella pyrenoidosa at low concentrations but inhibited it at high concentrations.The maximum promotion was 17.39%,which was ascribed to the accelerated photosynthetic rate and the enhanced CAT activity in algal cells when exposed to CIP.All these five antibiotics showed some promotion effect on TP.This work could provide reference for assessment of the potential risks of these five antibiotics on aquatic ecosystems.关键词
喹诺酮/四环素/蛋白核小球藻/毒性机制Key words
quinolone/tetracycline/Chlorella pyrenoidosa/toxic mechanism分类
资源环境引用本文复制引用
杜隆达,覃礼堂,莫凌云,梁延鹏,宋晓红,曾鸿鹄..喹诺酮和四环素两类抗生素对蛋白核小球藻的生理生化响应[J].日用化学工业（中英文）,2024,54(5):542-549,8.基金项目
广西科技重大专项(桂科No.AA20161001、桂科No.AA2016100403) （桂科No.AA20161001、桂科No.AA2016100403）
