药用层孔菌发酵液控油及收缩毛孔机理及功效研究OA北大核心CSTPCD

The fermentation broth of Fomes officinalis was obtained by two-way fermentation of Fomes officinalis and Lactococcus lactis,and the contents of active components in the fermentation broth and aqueous extract were detected.The effects of Fomes officinalis fermentation broth on oil control and pore contraction were studied from the aspects of molecule,cell,animal and human body.The fermentation of Fomes officinalis has higher content of active components,can reduce the production of ABTS free radicals,inhibit the expression of inflammatory factors TNF-α and IL-6,regulate the activity of 5α reductase,reduce skin oil secretion,promote the expression of type Ⅰ collagen(COL-Ⅰ),inhibit the expression of metalloproteinase-1(MMP-1),have the tendency of shrinking pores.It has the potential to become a cosmetic raw material with the effect of oil control and pore refining.