药学研究2024，Vol.43Issue(4)：338-341,4.DOI:10.13506/j.cnki.jpr.2024.04.005
表没食子儿茶素没食子酸酯与氟康唑联用抗耐药白色念珠菌的协同作用及机制
Synergistic effect and mechanism of epigallocatechin gallate and fluconazole against Candida albicans resistant isolates
摘要
Abstract
Objective To investigate the synergistic anti-infection effect of epigallocatechin gallate(EGCG)combined with fluconazole on drug-resistant CA and its mechanism of action.Methods Six strains of drug-resistant CA were selected and evaluated by checkerboard microdilution test with fractional inhibitory concentration index(FICI).The effect of the combination of the two drugs on the growth of mycelia was observed by fluorescence microscope.Results By FICI evaluation,it was confirmed that EGCG combined with FLC had a very good synergistic action against drug resistant CA,and the synergistic effect of the two was probably related to the inhibition of mycelial growth.Conclusion EGCG com-bined with FLC has synergistic action against drug resistant CA,and the synergistic mechanism may be related to inhibition of mycelial growth.关键词
耐药白色念珠菌/氟康唑/表没食子儿茶素没食子酸酯/协同作用/菌丝Key words
Drug-resistant Candida albicans/Fluconazole/Epigallocatechin gallate/Synergistic effect/Hyphal分类
药学引用本文复制引用
张柳平,李灿,李秀云,王菲菲..表没食子儿茶素没食子酸酯与氟康唑联用抗耐药白色念珠菌的协同作用及机制[J].药学研究,2024,43(4):338-341,4.基金项目
山东省自然科学基金(No.ZR2020QH365) （No.ZR2020QH365）
