药学研究2024，Vol.43Issue(4)：366-372,413,8.DOI:10.13506/j.cnki.jpr.2024.04.010
水凝胶微针技术的应用进展
Application progress of hydrogel-forming microneedle technology
摘要
Abstract
Hydrogel-forming microneedle is a novel type of polymeric microneedle that has gained much attention lately.When inserted into the skin,it absorbs the interstitial fluid to form continuous and unobstructed micropores that allow drugs to enter the body through the gaps in the network structure.Hydrogel-forming microneedle has high drug loading ca-pacity,adjustable drug release rate,and lack of residual needles,making it become a research hotspot in recent years.This study aims to present a thorough review of the applications of hydrogel-forming microneedle technology in skin interstitial fluid sampling and biomarker analysis,wound treatment,antitumor,drug reservoir,and other areas in recent years while of-fering insights into its future research prospects.关键词
水凝胶微针/生物标志物分析/伤口治疗/抗肿瘤/药物储库Key words
Hydrogel-forming microneedle/Biomarker analysis/Wound treatment/Antitumor/Drug reservoir分类
药学引用本文复制引用
陈雯琳,马超,张奕雯,袁华,郭娜,张峻颖..水凝胶微针技术的应用进展[J].药学研究,2024,43(4):366-372,413,8.基金项目
国家自然科学基金(No.81473357、82074128) （No.81473357、82074128）
云南省吴春勇专家工作站(2023) （2023）
