HDL向肝转运的生物学基础及作为药物载体应用的研究进展OACSTPCD
Research progress on the biological basis of HDL transport to liver and its application as drug carrier
仿生纳米颗粒给药系统在高效递释方面具有巨大潜力.而高密度脂蛋白(high-density lipoprotein,HDL)作为天然纳米颗粒,具有高效运输性、高度安全性、特异靶向性和极强穿透性等特点,具有作为药物载体应用的潜能.仿生HDL的纳米药物传输系统研究越来越受到关注.本文综述了HDL的组成、结构、代谢等生物学基础及人工重构的HDL作为药物载体结构设计、制备方法及应用研究现状,以期为HDL药物载体材料的深入研究提供理论指导.
The development of biomimetic nanoparticle drug delivery systems is an emerging field with enormous poten-tial for efficient drug delivery.High density lipoprotein(HDL),as a natural nanocarrier,possesses features such as high transport efficiency,high safety,specific targeting,and strong penetrabillity,making it a potential drug carrier.The research on HDL-based nanoparticle drug delivery systems is increasingly gaining attention.This article reviewed the biological basis of HDL,including its composition,structure,metabolism,and its current status of research and application as a drug carrier of reconstituted HDL.The aim of this article is to provide new ideas for the in-depth study of HDL as drug carrier materials.
金许曈;江子贤;王馨怡;田吉来
南京中医药大学泰州校区,江苏 泰州 225300南京中医药大学医学院·整合医学学院,江苏 南京 210023
药学
高密度脂蛋白逆向转运清道夫受体药物递送系统纳米药物
High-density lipoproteinReverse transportScavenger receptorDrug delivery systemNanomedicine
《药学研究》 2024 (004)
373-379 / 7
南京中医药大学大学生创新创业训练计划项目(No.103152022028);
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