药学研究2024，Vol.43Issue(4)：384-390,401,8.DOI:10.13506/j.cnki.jpr.2024.04.013
tPA溶栓引起的出血性转化机制及小分子化合物干预作用研究进展
Research progress on the mechanism of hemorrhagic transformation caused by tPA thrombolysis and the intervention effect of small molecule compounds
摘要
Abstract
Tissue type plasmin activator(tPA)is the only drug approved by the US Food and Drug Administration for the treatment of acute ischemic stroke.However,its clinical application is limited due to the narrow treatment time window and severe hemorrhagic transformation(HT).In this paper,the mechanism of HT development was reviewed from the per-spectives of blood-brain barrier disruption,neuroinflammation,oxidative stress,and nitrite stress,as well as the research progress of small molecule compounds on HT protection published in domestic and foreign journals in the past seven years.This information would provide some clues and references for the new drug development and drug combination for the ische-mic stroke.关键词
组织型纤溶酶原激活剂/出血性转化/小分子化合物/研究进展Key words
Tissue plasmin activator/Hemorrhagic transformation/Small molecule compounds/Research progress分类
医药卫生引用本文复制引用
黄娟,张米玲,余俊河,宫帅帅,寇俊萍..tPA溶栓引起的出血性转化机制及小分子化合物干预作用研究进展[J].药学研究,2024,43(4):384-390,401,8.基金项目
江苏省自然科学基金(No.SBK20210432) （No.SBK20210432）
