他莫昔芬联合左炔诺孕酮对大鼠子宫肌瘤的影响及机制研究OACSTPCD
Effects of tamoxifen combined with levonorgestrel on uterine fibroids in rats and their mechanism
目的:探讨他莫昔芬联合左炔诺孕酮对大鼠子宫肌瘤的影响及其作用机制.方法:选择SPF级成年雌性SD大鼠30只,采用苯甲酸雌二醇联合黄体酮腹腔注射建立子宫肌瘤模型.将大鼠随机分为对照组(正常大鼠2 ml 0.9％氯化钠溶液灌胃)、模型组(子宫肌瘤大鼠2 ml 0.9％氯化钠溶液灌胃)、他莫昔芬组(子宫肌瘤大鼠1.70 mg/kg他莫昔芬灌胃)、左炔诺孕酮组(子宫肌瘤大鼠0.1 mg/kg左炔诺孕酮灌胃)和联合组(子宫肌瘤大鼠他莫昔芬联合左炔诺孕酮灌胃…查看全部>>
Objective:To investigate the effects of tamoxifen combined with levonorgestrel on uterine fibroids in rats and their mechanism.Methods:Thirty adult female SD rats with SPF grade were selected to establish uterine fi-broid model by intrabitoneal injection of estradiol benzoate combined with progesterone.The rats were randomly di-vided into control group(normal rats were intragastric administration with 2 ml 0.9％sodium chloride solution),model group(uterine fi…查看全部>>
徐霞;张红;王鹏程;韩璐
上海交通大学医学院苏州九龙医院妇科,江苏苏州 215000苏州大学附属第一人民医院妇科,江苏苏州 215006上海交通大学医学院苏州九龙医院妇科,江苏苏州 215000上海交通大学医学院苏州九龙医院妇科,江苏苏州 215000
子宫肌瘤他莫昔芬左炔诺孕酮Wnt通路β-连环蛋白大鼠
Uterine fibroidsTamoxifenLevonorgestrelWnt pathwayBeta-cateninRats
《陕西医学杂志》 2024 (5)
589-592,597,5
江苏省青年医学重点人才项目(QNRC2016217)
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