陕西医学杂志2024，Vol.53Issue(5)：666-670,5.DOI:10.3969/j.issn.1000-7377.2024.05.020
罗沙司他治疗慢性肾脏病合并肾性贫血临床价值研究
Value of roxadustat in the treatment of chronic kidney disease complicated with renal anemia
摘要
Abstract
Objective:To investigate the clinical value of roxastat in the treatment of chronic kidney disease(CKD)complicated with renal anemia.Methods:A total of 102 patients with chronic kidney disease complicated with renal anemia were divided into observation group(45 cases)and control group(57 cases)according to different treatment methods.The control group was treated with recombinant human erythropoietin(rHuEPO)and the obser-vation group was treated with roxadustat for 12 weeks.The efficacy,anema-related indexes(hemoglobin[Hb],hem-atocrit[HCT],red blood cell count[RBC]),iron metabolism indexes(ferritin,serum iron,total iron binding capaci-ty),lipid metabolism indexes(cholesterol[CHOL],triglyceride[TG],low-density lipoprotein[LDL])and the oc-currence of adverse reactions were compared between the two groups.Results:At the 12th week of treatment,the to-tal effective rate of observation group was higher than that of control group(P＜0.05).At the 8th and 12th week of treatment,the ferritin levels of observation group were lower than those in of control group,and the serum iron and total iron binding capacity levels were higher than those of control group(all P＜0.05).At the 8th and 12th week of treatment,Hb levels in observation group were higher than those in control group,and TG and LDL levels were low-er than those in control group(all P＜0.05).At the 12th week of treatment,RBC and HCT of observation group were higher than control group,and CHOL was lower than control group(all P＜0.05).Within 12 weeks of treat-ment,there was no significant difference in the total incidence of adverse reactions between the two groups(P＜0.05).Conclusion:For patients with CKD complicated with renal anemia,roxadustat has better therapeutic effect than rHuEPO,can better improve anemia related indicators,regulate iron metabolism and lipid metabolism,and has good safety.关键词
慢性肾脏病/肾性贫血/罗沙司他/重组人促红细胞生成素/铁代谢/血脂代谢Key words
Chronic kidney disease/Renal anemia/Roxadustat/Recombinant human erythropoietin/Iron metabolism/Blood lipid metabolism分类
医药卫生引用本文复制引用
方修移,吴小冬,潘美娟,江丹丹,李龙..罗沙司他治疗慢性肾脏病合并肾性贫血临床价值研究[J].陕西医学杂志,2024,53(5):666-670,5.基金项目
贵州省卫生健康委员会科学技术基金资助项目(GZWKJ2021-141) （GZWKJ2021-141）
