陕西医学杂志2024，Vol.53Issue(5)：671-674,4.DOI:10.3969/j.issn.1000-7377.2024.05.021
核苷类似物治疗乙型肝炎肝硬化并发食管静脉曲张临床价值研究
Value of nucleoside analogues in the treatment of hepatitis B cirrhosis complicated with esophageal varices
摘要
Abstract
Objective:To investigate the clinical value of nucleoside analogues in the treatment of hepatitis B cir-rhosis complicated with esophageal varices.Methods:Eighty-eight patients with hepatitis B cirrhosis complicated with esophageal varices were selected and divided into control group(33 cases)and treatment group(55 cases)ac-cording to whether antiviral treatment was given.Liver function indexs(albumin[ALB],alanine aminotransferase[ALT],aspartate aminotransferase[AST],total bilirubin[TBIL]),Child-Pugh score and coagulation function inde-xes(prothrombin time[PT],prothrombin activity[PTA])were compared between the two groups before and after treatment.The negative conversion rate of hepatitis B virus DNA(HBV-DNA),the degree of esophageal varices and gastrointestinal bleeding were compared between two groups after treatment.Results:After antiviral treatment,TBIL,ALT and AST in treatment group were lower than before treatment,and ALB was higher than before treat-ment(all P＜0.05).After antiviral treatment,PT in the treatment group was lower than before treatment,and the treatment group was lower than the control group.PT A in the treatment group was higher than that before treat-ment,and the treatment group was higher than the control group(all P＜0.05).After antiviral treatment,the Child-Pugh score of the treatment group was lower than that before treatment,and the Child-Pugh score of the treatment group was lower than that of the control group(all P＜0.05).Compared with the control group,the negative conver-sion rate of HBV-DNA in the treatment group was increased after antiviral treatment(P＜0.05).In patients who did not receive EVL treatment,the reduction degree of esophageal varices in the treatment group was higher than that in the control group(P＜0.05).In patients who received EVL and those who did not receive EVL,the rate of gastrointestinal bleeding in the treatment group was lower than that in the control group(all P＜0.05).Conclusion:Nucleoside analogues can inhibit HBV virus replication in patients with hepatitis B cirrhosis complicated with esophageal varices,improve liver function and coagulation function,reduce the degree of esophageal varices,and reduce the risk of gastrointestinal bleeding.关键词
肝硬化/乙型肝炎病毒/食管静脉曲张/核苷类似物/消化道出血Key words
Cirrhosis/Hepatitis B virus/Esophageal varices/Nucleoside analogues/Gastrointestinal bleeding分类
医药卫生引用本文复制引用
王婷,邹百仓,董蕾,薛琼,王进海,陈芬荣..核苷类似物治疗乙型肝炎肝硬化并发食管静脉曲张临床价值研究[J].陕西医学杂志,2024,53(5):671-674,4.基金项目
陕西省重点研发计划项目(2022SF-460) （2022SF-460）
