陕西医学杂志2024，Vol.53Issue(5)：696-699,4.DOI:10.3969/j.issn.1000-7377.2024.05.027
宫颈癌患者血清微小RNA-195、双皮质素样激酶1、鳞状细胞癌抗原表达水平与临床病理特征及预后相关性研究
Relationship between serum microRNA-195,doublecortin-like kinase 1,squamous cell carcinoma antigen levels and clinicopathological features and prognosis in patients with cervical cancer
摘要
Abstract
Objective:To investigate the relationship between serum levels of microRNA(miR)-195,doublecortin-like kinase 1(DCLK1),squamous cell carcinoma antigen(SCC-Ag)and clinicopathological features and prognosis in patients with cervical cancer.Methods:Seventy-two patients with cervical cancer were selected as the observation group and 60 healthy women were selected as the control group.The expression levels of serum miR-195,DCLK1 and SCC-Ag of the two groups were compared.The correlation between serum miR-195,DCLK1,SCC-Ag and clinicopathological features of cervical cancer patients was analyzed by Spearman method.The patients were followed up for 3 years and their survival was record.Cox regression model was used to analyze the prognostic factors of patients with cervical cancer.Results:The serum levels of DCLK1 and SCC-Ag in the observation group were higher than those in the control group,and the levels of miR-195 were lower than those in the control group(all P＜0.05).Serum miR-195 level was negatively correlated with lymph node me-tastasis,FIGO stage and tumor differentiation degree,DCLK1 level was positively correlated with FIGO stage and tumor dif-ferentiation degree,SCC-Ag level was positively correlated with tumor differentiation degree and tumor diameter(all P＜0.05).The 3-year survival rate of patients with high expression of miR-195 was higher than that of patients with low ex-pression,and the 3-year survival rate of patients with high expression of DCLK1 and SCC-Ag was lower than that of patients with low expression(all P＜0.05).FIGO stage,degree of differentiation,lymph node metastasis,tumor diameter and serum levels of miR-195,DCLK1 and SCC-Ag were independent factors influencing prognosis of cervical cancer patients(all P＜0.05).Conclusion:Serum levels of DCLK1 and SCC-Ag are increased and miR-195 is decreased in patients with cervical cancer,which are related to clinicopathological features and prognosis,and are independent factors influencing prognosis of patients with cervical cancer.关键词
宫颈癌/微小RNA-195/双皮质素样激酶1/鳞状细胞癌抗原/临床病理特征/预后Key words
Cervical cancer/microRNA-195/Doublecortin-like kinase 1/Squamous cell carcinoma antigen/Clinicopathological features/Prognosis分类
医药卫生引用本文复制引用
惠玉洁,朱林凤,李卫民,赵雪燕,成叶利..宫颈癌患者血清微小RNA-195、双皮质素样激酶1、鳞状细胞癌抗原表达水平与临床病理特征及预后相关性研究[J].陕西医学杂志,2024,53(5):696-699,4.基金项目
北京市自然科学基金资助项目(7174317) （7174317）
北京市平谷区医院青年人才科研项目(PGYYQN2022-05) （PGYYQN2022-05）
