陕西医学杂志2024，Vol.53Issue(5)：710-713,4.DOI:10.3969/j.issn.1000-7377.2024.05.031
铁死亡在系统性红斑狼疮中的作用研究进展
Research progress on the role of ferrosis in systemic lupus erythematosus
摘要
Abstract
Systemic lupus erythematosus(SLE)is a diffuse connective tissue disease of unknown etiology asso-ciated with autoantibody production and inflammation.Iron death is a kind of cell death mode characterized by exces-sive accumulation of iron and excessive oxidation of lipids.The core of iron death mainly includes abnormal amino acid metabolism,lipid metabolism,iron metabolism and other metabolic abnormalities.At present,it has been found that a variety of immune cells closely related to SLE are closely related to iron death,and iron homeostasis and hepci-din,which maintains its balance,are also strongly related to SLE.This article reviews the mechanism of iron death and the potential relationship between iron death and SLE,and provides new ideas for the treatment of SLE.关键词
系统性红斑狼疮/铁死亡/中性粒细胞/淋巴细胞/巨噬细胞/铁调素Key words
Systemic lupus erythematosus/Ferroptosis/Neutrophils/Lymphocytes/Macrophages/Hepcidin分类
医药卫生引用本文复制引用
王赓丰,崔家康,孟庆良..铁死亡在系统性红斑狼疮中的作用研究进展[J].陕西医学杂志,2024,53(5):710-713,4.基金项目
国家自然科学基金资助项目(81874456) （81874456）
