陕西医学杂志2024，Vol.53Issue(5)：714-717,4.DOI:10.3969/j.issn.1000-7377.2024.05.032
巨噬细胞在心肌梗死中的作用研究进展
Research progress on the role of macrophages in myocardial infarction
摘要
Abstract
In recent years,myocardial infarction(MI)has been regarded as an inflammatory disease,and the in-flammatory response after MI affects the degree of myocardial damage and the remodeling of the heart structure.Macrophages play a key role in the process of inflammation.With functional plasticity,macrophages can be polarized into different phenotypes according to different microenvironments.They are mainly divided into pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages.Therefore,this article reviews the origin of macrophages,classical polarization theory,surface expression molecules and markers,relevant signaling pathways and their roles in myocardial infarction,including the role of macrophages in neovascularization and cardiomyocyte regeneration.关键词
心肌梗死/巨噬细胞/M1型巨噬细胞/M2型巨噬细胞/炎症反应/信号通路Key words
Myocardial infarction/Macrophages/M1 macrophages/M2 macrophages/Inflammatory response/Signaling pathways分类
医药卫生引用本文复制引用
周子程,张润峰..巨噬细胞在心肌梗死中的作用研究进展[J].陕西医学杂志,2024,53(5):714-717,4.基金项目
四川省科技计划项目(2020YJ0495) （2020YJ0495）
