陕西医学杂志2024，Vol.53Issue(5)：718-720,封3,4.DOI:10.3969/j.issn.1000-7377.2024.05.033
微流控技术在过继细胞免疫治疗中的应用研究进展
Research progress in application of microfluidic technology in adoptive cell immunotherapy
雷云昊 1雷永刚2
作者信息
- 1. 大连医科大学医学影像学院,辽宁大连 116000
- 2. 渭南市中心医院泌尿外科,陕西渭南 714000
- 折叠
摘要
Abstract
Adoptive cell therapy(ACT)is a individualized therapy that uses T cells from a patient's own body or a donor to be genetically enhanced in vitro and then reintroduced into the patient to fight specific cancer cells or in-fectious agents.However,ACT has many limitations,such as multi-step time-consuming and costly.Microfluidic technology(MT)is a technology that analyzes and operates microfluidic chips and microvalve systems manufactured with the help of microfabrication technology based on microchannel flow.The microfluidic platform has the advanta-ges of high integration,high efficiency,high throughput,and low sample requirements,which can effectively simplify ACT preparation steps,reduce production costs,explore multiple factors in the drug development process,and simu-late the tumor microenvironment.This article reviews the application of MT in cell sorting,cell proliferation and pre-clinical assay and drug evaluation in ACT therapy,as well as its application in other tumor immunotherapies.关键词
过继细胞疗法/微流控技术/免疫治疗/细胞分选/细胞增殖/临床前检测/药物评估Key words
Adoptive cell therapy/Microfluidic technology/Immunotherapy/Cell sorting/Cell proliferation/Preclinical assays/Drug evaluation分类
医药卫生引用本文复制引用
雷云昊,雷永刚..微流控技术在过继细胞免疫治疗中的应用研究进展[J].陕西医学杂志,2024,53(5):718-720,封3,4.
