脑胶质瘤组织ZEB2、CCL20表达及其与患者预后的相关性OA北大核心CSTPCD

Objective To investigate the expression of zinc finger E-box-binding protein 2(ZEB2)and CC chemokine ligand 20(CCL20)in glioma tissue and their relationship with prognosis.Methods The tumor tissues of 156 patients with glioma were collected as tumor group and 52 normal brain tissues of the same period were collected as normal group.The expression of ZEB2 and CCL20 in tissues were detected by immunohistochemistry,and the relationship between the expression and survival was analyzed by Kaplan-Meier survival curve.Patients in the tumor group were followed up for three years and grouped into a poor prognosis group and a good prognosis group based on their survival status,and the prognostic factors were analyzed by COX regression.Results The positive expression rate of ZEB2 and CCL20 in the tumor group were higher than those in the normal group(P＜0.05).The 3-year survival rate of 156 glioma patients was 69.87%.The survival rate of patients with positive ZEB2 and CCL20 expression was lower than that of patients with negative expression(P＜0.001).Age,maximum tumor diameter,tumor pathological grade,and positive expression of ZEB2 and CCL20 were all risk factors for poor prog-nosis of patients with glioma(P＜0.05),and preoperative KPS,postoperative radiotherapy,and course of temo-zolomide treatment were all protective factors(P＜0.05).Conclusion The expression level of ZEB2 and CCL20 in tumor tissues of glioma patients is up-regulated,and related to the prognosis of patients.