单纯手术与手术联合糖皮质激素治疗肿块型肉芽肿性乳腺炎的临床疗效OA北大核心CSTPCD
Clinical efficacy of simple surgery and surgery combined with glucocorticoids in the treatment of mass type granulomatous mastitis
目的 对比分析单纯手术与手术联合糖皮质激素治疗肿块型肉芽肿性乳腺炎(GM)的临床疗效、复发情况及乳房外观评价.方法 本研究回顾性分析2017年1月至2022年1月就诊于宜昌市中心人民医院甲乳外科的106例肿块型GM患者.依据就诊期间治疗手段不同,分为A组(单纯手术治疗,n = 67)和B组(手术联合糖皮质激素治疗,n = 39).观察比较两组患者的一般资料及临床资料,通过随访获得患者临床疗效、至临床治愈时长(TTCR)、1年内复发率及乳房外观评价情况.结果 经治疗后比较两组患者预后情况,手术联合糖皮质激素治疗组患者在临床治愈率、1年内复发率两方面均优于单纯手术组(P<0.05),此外,手术联合激素治疗后患者乳房外观优良率(92.31%)明显高于单纯手术组(88.06%),两组之间比较差异有统计学意义(P<0.05).结论 手术联合糖皮质激素治疗肿块型GM能够有效提高患者总体临床治疗效果,降低短期复发率,同时在保证乳房外观完整性方面效果显著,且小剂量口服激素类药物不良反应少,安全性高.
Objective To compare and analyze the clinical efficacy,recurrence rate,and breast appear-ance evaluation of simple surgery and surgery combined with glucocorticoids in the treatment of mass type granuloma-tous mastitis.Methods This study retrospectively analyzed 106 patients with nodular granulomatous mastitis who visited the Department of Breast Surgery at Yichang Central People's Hospital from January 2017 to January 2022 as the study subjects.According to the different treatment methods during the visit,patients were divided into Group A with simple surgical treatment(n = 67)and Group B with surgery combined with glucocorticoid treatment(n = 39).The general information and clinical indicators of the two groups of patients were observed and compared.Obtain patient clinical efficacy,time to clinical cure(TTCR),recurrence rate within one year,and breast appearance evaluation through follow-up.Results The prognosis of the follow-up patients after treatment showed that Group B patients had better clinical cure rate and one-year recurrence rate than the simple surgery group(P<0.05).More-over,the difference in breast appearance evaluation between the two groups was statistically significant,with Group B patients having a significantly higher rate of excellent appearance(88.06%)than Group A(92.31%).According to statistics,only 5.13%of patients in Group B experienced gastrointestinal reactions within one year after taking hormone therapy.Conclusions The combination of surgery and glucocorticoids in the treatment of mass type GM can effectively improve the overall clinical treatment effect of patients,reduce the short-term recurrence rate,and have a significant effect on ensuring the integrity of breast appearance.At the same time,low-dose oral steroid drugs have fewer adverse reactions and high safety.
崔天玥;欧阳理权;张胜初
三峡大学第一临床医学院(宜昌市中心人民医院伍家院区)甲乳外科(湖北宜昌 443000)浙江中医药大学附属第二医院(浙江省新华医院)甲乳外科(杭州 310005)
临床医学
肉芽肿性乳腺炎糖皮质激素手术治疗临床治愈率复发率
granulomatous mastitisglucocorticoidssurgical treatmentclinical cure raterecur-rence rate
《实用医学杂志》 2024 (009)
1268-1274 / 7
湖北省教育厅科学技术研究计划优秀中青年人才项目(编号:Z2021230)
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