摘要
Abstract
Objective To investigate the clinical effects of intense pulsed light(IPL)combined with 0.03%tacrolimus ointment and essence lotion for repairing skin barrier in the treatment of erythema telangiectasia rosacea(ETR).Methods From January 2021 to December 2022,63 patients with ETR were selected as the research objects,and divided into observation group(31 patients treated with IPL combined with essence lotion for repairing skin barrier)and control group(32 patients treated with 0.03%tacrolimus ointment)according to random digital tables.Treatment effects,symptom scores,skin barrier function indicators such as transepidermal water loss(TEWL),erythema index,skin moisture content and sebum,and the incidence rates of adverse reactions in the two groups during follow-up were compared.Results The total effective rate in the observation group was 96.77%,higher than 75.00%in the control group(P＜0.05).After treatment,facial pruritus,burning,tightness,persistent erythema and telangiectasia on the cheek of both groups were significantly alleviated.After treatment,clinical symptom scores of the two groups decreased,and the observation group had lower scores than the control group(P＜0.05).After treatment,erythema index and TEWL in the two groups decreased,and were lower in the observation group than in the control group.Sebum and skin moisture content increased,and were higher in the observation group than in the control group(P＜0.05).The total incidence of adverse reactions in the observation group during follow-up was 6.45%,lower than 25.00%in the control group(P=0.082).Conclusion Intense pulsed light combined with 0.03%tacrolimus ointment and essence lotion for repairing skin barrier is effective in the treatment of ETR.It can significantly relieve clinical symptoms,improve skin barrier function and reduce adverse reactions with high safety.关键词
红斑毛细血管扩张型玫瑰痤疮/强脉冲光/他克莫司/临床效果Key words
erythema telangiectasia rosacea/intense pulsed light/tacrolimus ointment/clinical effect分类
医药卫生
