中国免疫学杂志2024，Vol.40Issue(4)：736-740,5.DOI:10.3969/j.issn.1000-484X.2024.04.011
昆仙胶囊相关方案治疗狼疮肾炎的有效性:网状Meta分析
Efficacy of Kunxian capsule in treating patients with lupus nephritis:A network Meta-analysis
李子锋 1范玉玲 1易文 1侯晓强 1尹龙 1常彩云1
作者信息
- 1. 三峡大学第一临床医学院,宜昌市中心人民医院中医科,宜昌 443000
- 折叠
摘要
Abstract
Objective:To systematically evaluate the effectiveness of Kunxian capsule related regimens for patients with lupus nephritis(LN)in order to provide a reference basis for treatment strategies for LN patients.Methods:The computer searched the rele-vant studies of Kunxian capsule in PubMed,Web of Science,Cochrane Library,CBM,CNKI,Wanfang and VIP databases on the treatment of LN,the limited time for the establishment of the database is April 6,2022,and used R 4.0.2 software and Revman 5.3 software for Meta-analysis.Results:Four RCTs with 1 cohort study including 310 patients were finally included.The results of the Me-ta-analysis showed that:In terms of 24 h urinary protein and SLEDAI score,Glucocorticoid+Cyclophosphamide+Kunxian capsule achieved the best result after treatment;in terms of Scr,IgE,and IgG,the levels of each index were significantly lower in Glucocorti-coid+Cyclophosphamide+Kunxian capsules than in Glucocorticoid+Cyclophosphamide(P<0.05).Conclusion:The 5 regimens may work best as Glucocorticoids+Cyclophosphamide+Kunxian capsules in terms of clinical efficacy in treating LN patients.Because of the quality and quantity limitations of the included studies,more high-quality studies are needed for validation.关键词
昆仙胶囊/狼疮性肾炎/有效性/Meta分析Key words
Kunxian capsule/Lupus nephritis/Efficacy/Meta-analysis分类
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李子锋,范玉玲,易文,侯晓强,尹龙,常彩云..昆仙胶囊相关方案治疗狼疮肾炎的有效性:网状Meta分析[J].中国免疫学杂志,2024,40(4):736-740,5.
