中国免疫学杂志2024，Vol.40Issue(4)：752-755,4.DOI:10.3969/j.issn.1000-484X.2024.04.013
FGL2在胃肠间质瘤的表达及临床意义
Expression and clinical significance of FGL2 in GIST
张向莲 1王兴芬 1梁锐1
作者信息
- 1. 天津医科大学第二医院病理科,天津 300211
- 折叠
摘要
Abstract
Objective:To explore the expression and clinical significance of fibrinogen-like protein 2(FGL2)in gastrointesti-nal stromal tumor(GIST).Methods:Immunohistochemical EnVision two-step method was used to detect expression of FGL2 protein in 158 GIST patients,and correlation between FGL2 protein and clinicopathological parameters was analyzed,and relationship be-tween FGL2 protein and the count of CD3+T,CD8+T,CD20+T and CD68+T of tumor-infiltrating lymphocytes(TILs)in GIST was inves-tigated.Results:Expression of FGL2 protein in GIST was negatively correlated with tumor size,NIH risk grade,necrosis and mitotic image count(P<0.05),there was no significant difference in gender and tumor location(P>0.05).FGL2 expression was associated with low CD3+T cell counts in GIST(P<0.05),while there was no significantly difference with CD8+T,CD20+T and CD68+T cell counts(P>0.05).Conclusion:FGL2 protein is involved in occurrence and development of GIST,which expression level is partly pre-dictive of the malignant potential of GIST.FGL2 protein may participate in occurrence and development of GIST by regulating tumor microenvironment.关键词
纤维蛋白原样蛋白2/胃肠道间质瘤/肿瘤浸润相关淋巴细胞Key words
Fibrinogen-like protein 2/Gastrointestinal stromal tumor/Tumor infiltration of associated lymphocytes分类
医药卫生引用本文复制引用
张向莲,王兴芬,梁锐..FGL2在胃肠间质瘤的表达及临床意义[J].中国免疫学杂志,2024,40(4):752-755,4.
