中国免疫学杂志2024，Vol.40Issue(4)：846-856,11.DOI:10.3969/j.issn.1000-484X.2024.04.030
多种代谢物与巨噬细胞极性调节研究进展
Research progress on multiple metabolites and macrophage polarity regulation
摘要
Abstract
Macrophages are the most important type of innate immune cells,functional diversity and polarization plasticity are two of its important characteristics.Base on the perspective of polarization,macrophages are generally divided into two subgroups:M1 pro-inflammatory cells that kill pathogens and tumor cells,and M2 anti-inflammatory cells that promote tissue repair and angiogenesis.In addition,macrophages can actively adjust their own signals according to physiological changes or disease progression to polarize or reshape them in different directions,thereby tending to form macrophages with different functions and different phenotypes.Metabo-lites are one of the most important basic physiological and pathological activity characteristics and external factors.However,influence of metabolites on the polarity remodeling of macrophages during physiological changes or disease progression remains to be summa-rized.Therefore,as an entry point for exocrine metabolites or intracellular leakage metabolites,this review systematically summarizes the effects of different metabolites on polarization of macrophages and their mechanism of action.Sort out the effects of metabolite changes in pathological microenvironment of various diseases on the polarization of macrophages and their effects on disease progres-sion,aiming to explore the relationship between cell metabolites,macrophage polarization signals and the occurrence of diseases from a multi-factor and multi-dimensional perspective.关键词
巨噬细胞/极性重塑/代谢物/组织微环境/疾病发生Key words
Macrophages/Polarity remodeling/Metabolites/Organizational microenvironment/Disease occurrence分类
医药卫生引用本文复制引用
宋丹,辛彦龙,庞依心,王梦杰,林语诗,熊晓蕃,耿晶..多种代谢物与巨噬细胞极性调节研究进展[J].中国免疫学杂志,2024,40(4):846-856,11.基金项目
国家自然科学基金项目(32070891,32160165) （32070891,32160165）
陕西省千人计划青年项目(YJ0866) （YJ0866）
西藏自治区科技厅自然科学基金项目(XZ202201ZR0065G) （XZ202201ZR0065G）
陕西省自然科学基础研究计划项目(2020JQ-556). （2020JQ-556）
