新交泰饮对2型糖尿病大鼠糖脂代谢的影响OA

Objective To explore the effect of Xinjiaotai Decoction on blood glucose and lipid levels in type 2 diabetic rats.Methods A type 2 diabetic rat model was established using high-fat and high-sugar diet combined with a small dose of streptozotocin(STZ)injection.The rats were divided into a normal group,model group,metformin group(100 mg/kg),and Xinjiaotai Decoction low-dose(5.94 g/kg),medium-dose(11.88 g/kg),and high-dose(17.82 g/kg)groups,with 8 rats in each group.The rats were continuously intragastric administration for 4 weeks,and fasting blood glucose(FGB)was measured every week.After administration,the glucose tolerance(OGTT),serum insulin(INS),serum total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),aspartate aminotransferase(AST),alanine aminotransferase(ALT),tumor necrosis factor-alpha(TNF-α),interleukin 6(IL6)and other indicators were detected in each group of rats.Results Compared with metformin group,Xinjiao Taiyin medium dose group was weaker in reducing FGB and OGTT levels(P<0.05),but stronger in increasing INS secretion and decreasing TC,TG and LDL-C levels(P<0.05).Conclusion Xinjiaotai decoction can reduce the blood glucose level in type 2 diabetic rats,and its regulatory effect may be related to maintaining glucose tolerance,promoting insulin secretion and improving lipid metabolism.