疏肝化纤汤对乙肝肝硬化代偿期患者肝纤维化指标及炎症因子水平的影响OA

Objective To explore the effects of Shugan Huayxian decoction on hepatic fibrosis and inflammatory factors in patients with liver cirrhosis in compensatory stage.Methods A total of 120 patients with hepatitis B cirrhosis at compensatory stage admitted to Leshan Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected as the study objects and randomly divided into two groups.The control group(n=60)received conventional treatment,and the observation group(n=60)received Shugan Huxian decoction on the basis of the control group.The clinical efficacy,liver fibrosis indexes,inflammatory factors and the occurrence of adverse reactions were compared between the two groups.Results The effective rate of observation group was 91.67%,higher than that of control group 80.00%(P<0.05).After treatment,the levels of hyaluronic acid(HA),laminin(LN),type Ⅲ procollagen peptide(PC-Ⅲ),hypersensitive C-reactive protein(hs-CRP),interleukin-1β(IL-1β)and procalcitonin(PCT)in observation group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shugan Huayxian decoction can improve the clinical effect,improve the level of liver fibrosis and inflammatory factors,and has high safety.