中国药物经济学2024，Vol.19Issue(3)：68-71,4.DOI:10.12010/j.issn.1673-5846.2024.03.013
肝胆消炎片联合复方甘草酸苷注射液治疗铂类抗癌药致肝损伤的疗效
Curative Effect of Gandan Xiaoyan Tablet combined with Compound Glycyrrhizin Injection in the Treatment of Platinoid Anticancer Drug Induced Liver Injury
摘要
Abstract
Objective To explore the efficacy of Gandan Xiaoyan tablet combined with compound glycyrrhizin injection in the treatment of liver injury caused by platinoid anticancer drugs.Methods Sixty patients with liver injury caused by platinoid anticancer drugs admitted to Xinhui District Hospital of Traditional Chinese Medicine in Jiangmen City from January 2021 to January 2023 were selected as the study objects,and were divided into observation group(n=30,treated with Gandan Xiaoyan tablet combined with compound glycyrrhizin injection)and control group(n=30,treated with compound glycyrrhizin injection only)according to randomization method.The clinical efficacy,Liver function indicators[serum total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)],inflammatory factors[interleukin 6(IL6),monocyte chemoattractant protein-1(MCP-1),transforming growth factor-β(TGF-β),tumor necrosis factor-α(TNF-α)]levels before,and after treatment Quality of life after treatment and adverse reactions during treatment of the two groups were compared.Results After treatment,TBIL,ALT,AST,IL6,MCP-1 and TNF-α were decreased in both groups(P<0.05),and TBIL,ALT,AST,IL6,MCP-1 and TNF-α in observation group were lower than those in control group(P<0.05).After treatment,TGF-β was increased in both groups(P<0.05),and TGF-β in observation group was higher than that in control group(P<0.05).After treatment,the scores of physical function(PF),emotional function(EF)and total health status(QL)in observation group were higher than those in control group,while the scores of fatigue(FA),nausea and vomiting(NV),pain(PA),insomnia(SL)and loss of appetite(AP)in observation group were lower than those in control group,with statistical significance(P<0.05).There was no significant difference in the scores of role function(RF),cognitive function(CF),social function(SF),shortness of breath(DY),constipation(CO),diarrhea(DI)and economic hardship(FI)between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Gandan Xiaoyan tablet combined with compound glycyrrhizin injection has significant clinical efficacy in the treatment of liver injury caused by platinum-based anticancer drugs,which can effectively improve liver function and inflammatory response,improve the quality of life of patients,and have fewer adverse reactions,and have high clinical application value.关键词
药物性肝损伤/肝功能指标/炎症因子/肝胆消炎片/复方甘草酸苷注射液Key words
Drug-induced liver injury/Liver function index/Inflammatory cytokines/Hepatobiliary Xiaoyan tablet/Compound glycyrrhizic acid injection分类
医药卫生引用本文复制引用
刘晓兰,潘萍,伍欣瑜..肝胆消炎片联合复方甘草酸苷注射液治疗铂类抗癌药致肝损伤的疗效[J].中国药物经济学,2024,19(3):68-71,4.基金项目
江门市卫生计划局科学技术研究项目(21A079) （21A079）
