中国医院用药评价与分析2024，Vol.24Issue(4)：396-400,407,6.DOI:10.14009/j.issn.1672-2124.2024.04.003
基于网络药理学探讨祛痰合剂祛痰镇咳的作用机制
Mechanism of Expectorant Mixture in the Treatment of Productive Cough Based on Network Pharmacology
摘要
Abstract
OBJECTIVE:To explore the mechanism of expectorant mixture in the treatment of productive cough based on network pharmacology.METHODS:Components of expectorant mixture were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,Symmap database and BATMAN database.The effective components of expectorant mixture were screened by oral bioavailability≥30%and drug-likeness≥0.18.Pubchem database and SwissTargetPrediction database were used to screen the active components and predict the targets,the disease-drug-component-target network was constructed by Cytoscape.Protein-protein interaction network of the targets were constructed by STRING and the key targets were calculated by R language.Finally,gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of related targets were performed by using the DAVID database.RESULTS:Totally 22 potential active components and 298 drug-disease related targets were screened out,which indicated that expectorant mixture might play a role in the treatment of productive cough by regulating some biological processes including response to drug,phospholipase C-activating G-protein coupled receptor signaling pathway and positive regulation of cell proliferation,and some molecular functions such as enzyme binding,protein kinase activity and drug binding.The mechanism might be closely related to the regulation of neuroactive ligand-receptor interaction,cyclic adenosine monophosphate signaling pathway and calcium signaling pathway.CONCLUSIONS:Expectorant mixture can exert the mechanisms of treating productive cough through multi-components,multi-targets and multi-pathways,which lays the research foundation for further exploring the mechanism.关键词
祛痰合剂/祛痰镇咳/网络药理学/作用机制Key words
Expectorant mixture/Productive cough/Network pharmacology/Mechanism分类
医药卫生引用本文复制引用
郭思瑞,徐硕,徐文峰,金鹏飞..基于网络药理学探讨祛痰合剂祛痰镇咳的作用机制[J].中国医院用药评价与分析,2024,24(4):396-400,407,6.基金项目
国家自然科学基金资助项目(No.81803715) （No.81803715）
中央高水平医院临床科研业务费资助项目(No.BJ-2021-211) （No.BJ-2021-211）
