中国医院用药评价与分析2024，Vol.24Issue(4)：422-425,430,5.DOI:10.14009/j.issn.1672-2124.2024.04.008
补充维生素D改善终末期肾病患者氧化应激状态的研究
Improvement of Oxidative Stress in Patients with End-Stage Nephropathy by Vitamin D Supplementation
摘要
Abstract
OBJECTIVE:To probe into the improvement of oxidative stress in patients with end-stage nephropathy by vitamin D supplementation.METHODS:A total of 152 hemodialysis patients who were treated in the nephrology department of the First Affiliated Hospital of Xi'an Jiaotong University from Jun.2021 to May 2023 were extracted to be divided into the vitamin D group(n=76)and control group(n=76)via the random number table method.All patients received routine hemodialysis treatment,while the vitamin D group was given Calcitriol soft capsules.All patients received continuous treatment for 12 weeks.The vitamin D status and serum 25-hydroxyvitamin D[25(OH)D]levels were compared between the vitamin D group and control group before and after treatment.The oxidative stress indicators such as malondialdehyde(MDA),catalase(CAT),glutathione peroxidase(GSH-PX)and superoxide dismutase(SOD),subjective global assessment(SGA)scores and medical outcomes study 36-item short-form health survey(SF-36)scores were compared between two groups before and after treatment.The correlation between serum 25(OH)D and MDA,CAT,GSH-PX,SOD was evaluated by using Spearman correlation analysis.RESULTS:After treatment,the proportion of patients with vitamin D deficiency in the vitamin D group decreased significantly compared with the control group(χ2 =16.473,P<0.001),the proportion of patients with normal vitamin D in the vitamin D group increased significantly compared with the control group(χ2 =26.621,P<0.001),and the 25(OH)D value increased significantly compared with the control group(t = 4.580,P<0.001),with statistically significant differences.After treatment,MDA in the vitamin D group decreased significantly compared with the control group(t= 5.453,P<0.001),while CAT(t=11.068,P<0.001),GSH-PX(t=15.129,P<0.001)and SOD(t=4.976,P<0.001)increased significantly compared with the control group,with statistically significant differences.After treatment,the SGA scores of vitamin D group were significantly lower than those of the control group(t=6.482,P<0.001),while the SF-6 scores was significantly higher than those of the control group(t=7.015,P<0.001),with statistically significant differences.Spearman correlation analysis showed that serum 25(OH)D level in patients was negatively correlated with MDA(r =-0.332,P = 0.015),and positively correlated with CAT(r = 0.392,P = 0.030),GSH-PX(r = 0.673,P = 0.047),and SOD(r = 0.288,P = 0.026).CONCLUSIONS:Vitamin D supplementation can increase the serum GSH-PX,CAT and SOD of patients with ESRD,reduce the serum MDA level,improve the oxidative stress and nutritional status,and enhance the quality of life in patients.The incidence rate of vitamin D deficiency in patients with ESRD is high,serum 25(OH)D level is closely related to oxidative stress indicators such as MDA,CAT,GSH-PX and SOD.关键词
终末期肾病/氧化应激/维生素DKey words
End-stage nephropathy/Oxidative stress/Vitamin D分类
医药卫生引用本文复制引用
刘婷婷,罗宇,范建宁,张李婷,张玮,张卫平..补充维生素D改善终末期肾病患者氧化应激状态的研究[J].中国医院用药评价与分析,2024,24(4):422-425,430,5.基金项目
2021年陕西省卫生健康委员会卫生健康科研项目(No.2021JQ592) （No.2021JQ592）
