中国医院用药评价与分析2024，Vol.24Issue(4)：431-434,4.DOI:10.14009/j.issn.1672-2124.2024.04.010
当归补血汤联合回旋灸对CKD 3-5期非透析糖尿病肾病合并肾性贫血的临床研究
Clinical Study of Danggui Buxue Decoction Combined with Circling Moxibustion in CKD 3-5 Non-Dialysis Diabetes Nephropathy Complicated with Renal Anemia
摘要
Abstract
OBJECTIVE:To probe into the effects of Danggui Buxue decoction combined with circling moxibustion on glomerular filtration function,vascular calcification,intestinal endotoxin level and hepcidin-25,β-hydroxybutyrate(β-HB)in patients with chronic kidney disease(CKD)3-5 non-dialysis diabetes nephropathy complicated with renal anemia.METHODS:A total of 102 patients with CKD 3-5 non-dialysis diabetes nephropathy complicated with renal anemia admitted into nephropathy and rheumatology department of the hospital from Dec.2021 to Feb.2023 were extracted and divided into the research group and control group by random number table method,with 51 patients in each group.On the basis of routine treatment(diet control,moderate exercise,oral rosastatin),the control group was treated with circling moxibustion,while the research group received Danggui Buxue decoction on the basis of the control group.Both groups were treated continuously for 3 months.After treatment,the efficacy of two groups was analyzed,and the glomerular filtration function,vascular calcification score,peripheral blood lipopolysaccharide(LPS),interleukin-6(IL-6),hepcidin-25 and β-HB levels were compared between two groups.RESULTS:The total effective rate of the research group was 96.08%(49/51),significantly higher than that 84.31%(43/51)of the control group,the difference was statistically significant(P<0.05).Compared with the control group,patients in the research group after treatment had higher glomerular filtration rate,lower abdominal aortic vascular calcification score,lower LPS,IL-6,hepcidin-25 and β-HB levels in peripheral blood,and higher hemoglobin,ferritin,transferrin saturation and transferrin contents in peripheral blood,the differences were statistically significant(P<0.05).CONCLUSIONS:The efficacy of Danggui Buxue decoction combined with circling moxibustion for improving anemia in patients with CKD 3-5 non-dialysis diabetes nephropathy complicated with renal anemia is significant,which can improve the glomerular filtration function and reduce the degree of vascular calcification,the mechanism may be related to reducing the level of lipopolysaccharide and regulating the level of hepcidin-25 and β-HB.关键词
糖尿病肾病/肾性贫血/非透析/当归补血汤/回旋灸/肾小球滤过功能/血管钙化Key words
Diabetes nephropathy/Renal anemia/Non-dialysis/Danggui Buxue decoction/Circling moxibustion/Glomerular filtration function/Vascular calcification分类
医药卫生引用本文复制引用
邹训霞,赵娜妹,蒋晓涵,李陈达,何美杉..当归补血汤联合回旋灸对CKD 3-5期非透析糖尿病肾病合并肾性贫血的临床研究[J].中国医院用药评价与分析,2024,24(4):431-434,4.基金项目
河北省科学技术研究与发展计划项目(No.202101A068) （No.202101A068）
保定市社发类项目(No.2241ZF271) （No.2241ZF271）
