中国医院用药评价与分析2024，Vol.24Issue(4)：435-438,4.DOI:10.14009/j.issn.1672-2124.2024.04.011
达格列净改善2型糖尿病患者肾血管功能、主动脉硬化和血管内皮功能障碍的研究
Improvement of Dapagliflozin on Renal Vascular Function,Aortic Sclerosis and Vascular Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
OBJECTIVE:To probe into the effects of dapagliflozin on renal vascular function,aortic sclerosis and vascular endothelial dysfunction in patients with type 2 diabetes mellitus(T2DM).METHODS:A total of 278 patients with T2DM treated in the endocrinology department of the hospital from Mar.2022 to Aug.2023 were extracted to be divided into the dapagliflozin group(n= 139)and control group(n= 139)according to the random number table method.The control group was treated with Metformin tablets orally,twice a day,0.5 g each time.On the basis of treatment in the control group,the dapagliflozin group was given oral treatment of Dapagliflozin tablets,once a day in the morning,10 mg each time.All patients were treated continuously for 4 weeks.The serum,urine,blood pressure and vessel function indicators were compared before and after treatment between the dapagliflozin group and control group.RESULTS:After treatment,the fasting blood glucose of the dapagliflozin group decreased significantly compared with the control group during the same period(t=2.815,P=0.005),24 h urine volume(t=5.166,P<0.001),urinary sodium(t = 2.021,P = 0.044),free water clearance(t = 21.971,P<0.001),and serum magnesium(t=6.863,P<0.001)increased significantly compared with the control group during the same period,while serum norepinephrine decreased significantly compared with the control group at the same period(t=6.279,P<0.001),with statistically significant differences.After treatment,the systolic blood pressure(t=3.426,P=0.001)and pulse wave velocity(t=4.790,P<0.001)in the dapagliflozin group decreased significantly compared with the control group,while the flow-mediated dilation increased significantly compared with the control group(t=9.316,P<0.001),with statistically significant differences.After treatment,the renal resistance index of dapagliflozin group decreased significantly compared with the control group during the same period,with statistically significant difference(t=6.038,P<0.001).CONCLUSIONS:T2DM patients treated with dapagliflozin shows significant improvement in vascular endothelial function,atherosclerosis and renal resistance index,significant reduction in blood pressure and blood glucose,and significant increase in serum magnesium and urinary sodium.关键词
达格列净/2型糖尿病/血管功能Key words
Dapagliflozin/Type 2 diabetes mellitus/Vascular function分类
医药卫生引用本文复制引用
冯舒雅,任常谕,周后凤,罗雪,杨婧..达格列净改善2型糖尿病患者肾血管功能、主动脉硬化和血管内皮功能障碍的研究[J].中国医院用药评价与分析,2024,24(4):435-438,4.基金项目
2021年四川省卫生健康委员会医学科技项目(No.21PJ149) （No.21PJ149）
