中国医院用药评价与分析2024，Vol.24Issue(4)：465-468,4.DOI:10.14009/j.issn.1672-2124.2024.04.018
苦参凝胶治疗外阴阴道假丝酵母菌病(湿热下注证)的药物经济学评价
Pharmacoeconomic Evaluation of Sophora Flavescens Gel in the Treatment of Vulvovaginal Candidiasis(Dampness-Heat Syndrome)
摘要
Abstract
OBJECTIVE:To evaluate the economics of Sophora flavescens gel in the treatment of vulvovaginal Candidiasis(VVC,dampness-heat syndrome).METHODS:From the perspective of health system,based on a published randomized controlled trial study on the treatment of VVC by Sophora flavescens gel,the negative conversion rate of candida in this study was used as the effect parameter,the cost parameters were obtained from the database of Menet.com,and the cost-effectiveness analysis was conducted by using TreeAge Pro software for Sophora flavescens gel in the treatment of VVC.RESULTS:Simulation results of decision tree model showed that after 14 d of treatment,the cost of Sophora flavescens gel combined with Clotrimazole vaginal tablet was 123.28 yuan,and the conversion rate of candida in vulva vagina was 0.93.The cost of using Clotrimazole vaginal tablet alone was 86.56 yuan,and the negative conversion rate of candida was 0.71.Compared with Clotrimazole vaginal tablet alone,Sophora flavescens gel combined with Clotrimazole vaginal tablet had higher cost and better efficacy,with an incremental cost-effectiveness ratio of 166.91 yuan,about 0.52%of per capita disposable income in China in 2020(32 189 yuan),and sensitivity analysis showed that the results were relatively robust.CONCLUSIONS:Based on the assumption that per capita disposable income is the patient's willing to pay threshold in China in 2020,the treatment regimen of Sophora flavescens gel combined with Clotrimazole vaginal tablet for VVC is more economical than Clotrimazole vaginal tablet alone.The development of this study is beneficial for clinicians to rationally use drugs or select more economical regimens,and can provide optimized reference for the allocation of health care resources.关键词
苦参凝胶/外阴阴道假丝酵母菌病/药物经济学/TreeAge ProKey words
Sophora flavescens gel/Vulvovaginal candidiasis/Pharmacoeconomics/TreeAge Pro分类
医药卫生引用本文复制引用
苏鑫鑫,崔鑫,黎元元,谢雁鸣..苦参凝胶治疗外阴阴道假丝酵母菌病(湿热下注证)的药物经济学评价[J].中国医院用药评价与分析,2024,24(4):465-468,4.基金项目
国家中医药管理局2021年岐黄学者支持项目(No.国中医药人教函[2022]6号) （No.国中医药人教函[2022]6号）
中央级公益性科研院所基本科研业务费专项资金资助项目(No.Z0737) （No.Z0737）
