中国中西医结合影像学杂志2024，Vol.22Issue(3)：245-249,261,6.DOI:10.3969/j.issn.1672-0512.2024.03.001
基于MRI增强扫描的影像组学对肝细胞癌Ki-67表达水平的术前预测价值
Value of enhanced MRI radiomics in preoperative prediction for Ki-67 expression in hepatocellular carcinoma
摘要
Abstract
Objective:To investigate the value of enhanced MRI radiomics to preoperatively predict Ki-67 expression in hepatocellular carcinoma(HCC).Methods:The clinical and enhanced MRI data of 101 HCC patients were retrospectively analyzed.A threshold of 10%was used to classify the Ki-67 high expression(62 cases)and low expression(39 cases).Radiomics features were extracted from the tumor regions of enhanced MRI at the arterial phase(AP),portal venous phase(PVP),and delayed phase(DP).Single-phase and three-phase combined radiomics logistic regression models were constructed using five-fold cross-validation in the training cohort(80 cases).Combined with the clinical data and image features of the patients,a clinical-imaging-radiomics combined model was established.The diagnostic efficacy of each model was compared by ROC curve.Finally,the validation cohort(21 cases)was verified,and the best diagnostic model was selected.Results:The maximum diameter and the edge of the tumor were independent risk factors for the high expression of Ki-67.The clinical-imaging regression model showed that the AUCs of the diagnostic efficacy of the training cohort and the validation cohort were 0.764 and 0.759,respectively.The AUCs of the AP,PVP,DP and three-phase combined model of enhanced MRI in the training cohort were 0.819,0.804,0.865,0.915,and those in the validation cohort were 0.730,0.720,0.807,0.843,respectively.The AUCs of the clinical-imaging-radiomics combined model for the training cohort and the validation cohort were 0.924,0.880,respectively.Conclusion:The clinical-imaging-radiomics combined model based on enhanced MRI can provide a great value in preoperative prediction for Ki-67 expression in HCC.关键词
磁共振成像/影像组学/Ki-67/癌,肝细胞Key words
Magnetic resonance imaging/Radiomics/Ki-67/Carcinoma,hepatocellular引用本文复制引用
王文剑,黄京城,杨鑫,杭嘉乐,孙骏,傅剑雄,叶靖,罗先富..基于MRI增强扫描的影像组学对肝细胞癌Ki-67表达水平的术前预测价值[J].中国中西医结合影像学杂志,2024,22(3):245-249,261,6.基金项目
苏北人民医院第七批院级扶持技术项目(FCJS202352). （FCJS202352）
